Results 41 to 50 of about 6,718 (165)

Does targeting Arg98 of FimH lead to high affinity antagonists?

, 2021
Bacterial resistance has become an important challenge in the treatment of urinary tract infections. The underlying resistance mechanisms can most likely be circumvented with an antiadhesive approach, antagonizing the lectin FimH located at the tip of ...
Reisner, Andreas, Anderluh, Marko, Tomašič, Tihomir, Rabbani, Said, Maier, Timm, Jakopin, Žiga, Jakob, Roman P., Ernst, Beat   +7 more
core   +1 more source

Orthogonal photoswitching of heterobivalent azobenzene glycoclusters: the effect of glycoligand orientation in bacterial adhesion

Beilstein Journal of Organic Chemistry
Carbohydrate recognition is fundamental to a plethora of cellular processes and hence the elucidation of the structural determinants of the recognition process is a prerequisite for understanding and manipulating carbohydrate–protein interactions, such ...
Leon M. Friedrich, Thisbe K. Lindhorst
doaj   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Escherichia coli K1 RS218 Interacts with Human Brain Microvascular Endothelial Cells via Type 1 Fimbria Bacteria in the Fimbriated State

, 2005
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E.
Shin, S., Kim, K.J., di Cello, F., Cai, M., Khan, Naveed Ahmed, Xie, Y., Kim, K.S., Teng, C.H.   +7 more
core   +1 more source

Kinetic and Thermodynamic Characterization of the Bacterial Lectin FimH [PDF]

, 2021
One fundamental aim of drug discovery is the development of new molecular entities that have a considerably advantage over already existing therapies. Urinary tract infections (UTIs) urgently require an alternative to the conventional antibiotic therapy ...
Silbermann, Marleen
core  

Differential Stability and Trade-Off Effects of Pathoadaptive Mutations in the Escherichia coli FimH Adhesin†

, 2007
FimH is the tip adhesin of mannose-specific type 1 fimbriae of Escherichia coli, which are critical to the pathogenesis of urinary tract infections. Point FimH mutations increasing monomannose (1M)-specific uro-epithelial adhesion are commonly found in ...
Chesnokova, Veronika, Weissman, Scott J, Hooton, Thomas M, Evgeni V, Beskhlebnaya, Viktoriya, Stamm, Walter E, Sokurenko, Evgeni V, Chattopadhyay, Sujay   +7 more
core   +3 more sources

Multidrug resistance of bacterial pathogens in canine pyometra

Journal of Small Animal Practice, EarlyView.
Objectives To characterise multidrug antimicrobial resistance and pathogenicity profiles of bacteria isolated from different anatomical sites in bitches with pyometra, emphasising their clinical relevance for diagnosis and therapeutic decision‐making in small animal practice.
M. G. M. Camozzi, S. B. Waller, E. C. Castelhano, A. L. S. Neves, B. R. Arrais, J. F. N. Pinto, B. G. Alves, C. N. Moreira   +7 more
wiley   +1 more source

Construction of fimH chromosomal mutants.

, 2013
(A) Construction of fimH chromosomal mutants. (B) Electron microscopy examination of AIEC LF82 bacteria, LF82-ΔfimH isogenic mutant, LF82-ΔfimH/fimHLF82, LF82-ΔfimH/fimHK12, LF82-ΔfimH/fimH7082, LF82-ΔfimH/fimHLF28, LF82-ΔfimH/fimHLF16, LF82-ΔfimH ...
Jérémy Denizot (209615), Arlette Darfeuille-Michaud (112082), Margarita Martinez-Medina (277062), Alexander Mellmann (72273), Richard Bonnet (241637), Nicolas Barnich (277067), Nicolas Dreux (277061), Dagmara Kisiela (277064), Evgeni Sokurenko (277065), Sujay Chattopadhyay (158532), Jean-Frédéric Colombel (108372), Christel Neut (241629), Corinne Gower-Rousseau (277066), Maria Billig (277063)   +13 more
core   +1 more source

Emerging Dissemination of blaCTX‐M‐65 in Bovine E. coli in Spain Associated With IncHI2 Plasmids

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The resistome in ESBL/AmpC‐producing E. coli in livestock was diverse and dominated by plasmid‐borne genes Detection of host‐independent dissemination of AMR determinants mediated by shared plasmid types First report in Spanish cattle of blaCTX‐M‐65 on IncHI2 plasmids, an under‐reported ESBL in Europe Identification of potentially zoonotic clones in ...
Medelin Ocejo, Beatriz Oporto, Ana Hurtado   +2 more
wiley   +1 more source

Ligands for FimH

, 2011
Adhesion of bacteria to glycosylated cells and surfaces is largely facilitated through adhesive organells projecting from the bacterial surface, which are called fimbriae.
null Thisbe K. Lindhorst
core   +1 more source