Frontiers in Immunology, 2023 BackgroundMacrophages are key effector cells of innate immunity and play a critical role in the immune balance of disease pathogenesis, especially in the tumor microenvironment.
Wei Zhang +5 more
doaj +1 more source
Iranian Journal of Microbiology, 2021 Background and Objectives: This study aimed to investigate the accessible regions of the fimH mRNA using computational prediction and dot-blot hybridization to increase the effectiveness of antisense anti-virulence therapeutics against Uropathogenic ...
Elnaz Harifi Mood +5 more
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FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro
Pathogens, 2023 Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established pathogenic properties. The FimH adhesin subunit of type 1 pili plays a key role
Shelly Roselyn Van Eyssen +4 more
doaj +1 more source
Colistin and Biofilm-Related Genes of Positive Escherichia coli O157:H7 in Cattle (Bos taurus) Carcasses Antibiotic Resistance Profiles, Biofilm and Molecular Characterisation of Isolates. [PDF]
Vet Med SciAntimicrobial resistance in various infectious agents poses a public health threat. Therefore, this study aimed to determine the antibiotic resistance profiles, biofilm formation abilities and molecular characterisation of colistin‐resistant Escherichia coli O157:H7 from cattle carcasses.
Barel M +7 more
europepmc +2 more sources
Catch-bond mechanism of the bacterial adhesin FimH [PDF]
, 2016 Ligand-receptor interactions that are reinforced by mechanical stress, so-called catch-bonds, play a major role in cell-cell adhesion. They critically contribute to widespread urinary tract infections by pathogenic Escherichia coli strains.
Sauer, Maximilian M. +9 more
core +1 more source
Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections. [PDF]
Clin Transl SciABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Ali L, Sokhn ES, Khalil C, Saleh FA.
europepmc +2 more sources
In vitro and in vivo characterization of FimH antagonists for anti-adhesion therapy - an alternative therapeutic approach against urinary tract infection [PDF]
, 2014 Uropathogenic Escherichia coli (UPEC) are the major cause of urinary tract infections (UTI), which is one of the most common infectious disease worldwide.
Abgottspon, Daniela
core +1 more source
Synthesis and evaluation of glycomimetic antagonists for the lectins DC-SIGN and FimH [PDF]
, 2014 Lectins are carbohydrate-binding proteins that are widely spread in nature and crucially involved in a multitude of biological processes. This thesis addresses the design of glycomimetic antagonists for the human lectin DC-SIGN (chapter 2) and the ...
Mayer, Katharina
core +1 more source
Antagonizing the adhesion of type 1 fimbriae - mediated Escherichia coli - a novel therapy for urinary tract infections [PDF]
, 2015 Urinary tract infections (UTIs), primarily caused by uropathogenic E. coli (UPEC), affect millions of people and account for significant morbidity and high medical costs.
Pang, Lijuan
core +1 more source
Journal of Clinical and Translational Science, 2021 IMPACT: We are developing the 3D perfusion system for use with patient-derived bacteria to further characterize the mechanism behind bacterial-induced inflammation and cancer. OBJECTIVES/GOALS: We previously reported the adherent invasive E.
Rachel C Newsome +8 more
doaj +1 more source