Results 21 to 30 of about 7,588 (203)

Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection

Journal of Microbiology, Immunology and Infection, 2022
Background: FimH adhesin is proposed to enhance Escherichia coli kidney infection by acting with PapGII adhesin, but genetic epidemiology study and animal study have not been widely conducted to confirm this hypothesis.
Chin-Chung Tseng, Wei-Hung Lin, An-Bang Wu, Ming-Cheng Wang, Ching-Hao Teng, Jiunn-Jong Wu   +5 more
doaj   +2 more sources

Molecular Detection of Type 1 Fimbriae-Encoding Gene (fimH) in Uropathogenic Escherichia coli Strains Isolated from Outpatients with Urinary Tract Infection [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objective: Urinary Tract Infection (UTI) is one of the most common infections in all age groups. The majority of these infections are caused by Uropathogenic Escherichia coli (UPEC) strains. Colonization, attachment to uroepithelium, and the
Nemat Shams, Amin Jaydari
doaj   +3 more sources

A Novel Integrated Way for Deciphering the Glycan Code for the FimH Lectin [PDF]

Molecules, 2018
The fimbrial lectin FimH from uro- and enteropathogenic Escherichia coli binds with nanomolar affinity to oligomannose glycans exposing Manα1,3Man dimannosides at their non-reducing end, but only with micromolar affinities to Manα1,2Man ...
Tetiana Dumych, Clarisse Bridot, Sébastien G. Gouin, Marc F. Lensink, Solomiya Paryzhak, Sabine Szunerits, Ralf Blossey, Rostyslav Bilyy, Julie Bouckaert, Eva-Maria Krammer   +9 more
doaj   +5 more sources

Characterisation of Haemolytic Uropathogenic Escherichia coli Isolated From Dogs and Cats. [PDF]

Vet Med Sci
The present study characterises 51 canine and feline haemolytic E. coli isolates from urinary tract infections by a polyphasic approach, including susceptibility testing, CH‐clonotyping, and DNA microarrays. The majority of isolates belonged to phylogenetic group B2 and were classified as extraintestinal pathogenic E.
Büttner S, Spergser J, Makarova O, Szostak MP, Rosel AC, Ruppitsch W, Schäfer-Somi S, Müller E, Braun SD, Monecke S, Ehricht R, Künzel F, Loncaric I.   +12 more
europepmc   +2 more sources

FimH as a scaffold for regulated molecular recognition [PDF]

Journal of Biological Engineering, 2021
AbstractBackgroundRecognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks convenient regulation.
Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko, Wendy Evelyn Thomas   +5 more
openaire   +3 more sources

FimH‐mediated autoaggregation of Escherichia coli [PDF]

Molecular Microbiology, 2001
Autoaggregation is a phenomenon thought to contribute to colonization of mammalian hosts by pathogenic bacteria. Type 1 fimbriae are surface organelles of Escherichia coli that mediate d‐mannose‐sensitive binding to various host surfaces. This binding is conferred by the minor fimbrial component FimH.
Schembri, M. A., Christiansen, G., Klemm, P.   +2 more
openaire   +6 more sources

Evaluation of accessible regions of Escherichia coli fimH mRNA through computational prediction and experimental investigation

Iranian Journal of Microbiology, 2021
Background and Objectives: This study aimed to investigate the accessible regions of the fimH mRNA using computational prediction and dot-blot hybridization to increase the effectiveness of antisense anti-virulence therapeutics against Uropathogenic ...
Elnaz Harifi Mood, Alireza Japoni-Nejad, Mohammadreza Asadi Karam, Mohammad Pooya, Saeid Bouzari, Nader Shahrokhi   +5 more
doaj   +1 more source

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. [PDF]

PLoS Pathogens, 2008
Components of bacteria have been shown to induce innate antiviral immunity via Toll-like receptors (TLRs). We have recently shown that FimH, the adhesin portion of type 1 fimbria, can induce the innate immune system via TLR4.
Ali A Ashkar, Karen L Mossman, Brian K Coombes, Carlton L Gyles, Randy Mackenzie   +4 more
doaj   +1 more source

Linker insertion analysis of the FimH adhesin of type 1 fimbriae in anEscherichia coli fimH-null background [PDF]

FEMS Microbiology Letters, 1996
The gene encoding the Escherichia coli FimH adhesin of type 1 fimbriae has been subjected to linker insertion mutagenesis. Amino acid changes were introduced at a number of positions spanning the entire sequence in order to probe the structure-function relationship of the FimH protein. The effect of these mutations on the ability of bacteria to express
Schembri, Mark A., Pallesen, Lars, Connell, Hugh, Hasty, David L., Klemm, Per   +4 more
openaire   +5 more sources

Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance The evolution of multidrug resistance in pathogenic bacteria, including uropathogenic Escherichia coli (UPEC), that cause most urinary tract infections is becoming a worldwide crisis.
Drew J, Schwartz, Vasilios, Kalas, Jerome S, Pinkner, Swaine L, Chen, Caitlin N, Spaulding, Karen W, Dodson, Scott J, Hultgren   +6 more
openaire   +2 more sources