Integrins are transmembrane proteins that mediate cellular adhesion and migration to neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse physiological and pathological pathways.
Eun Jeong Park+8 more
doaj +1 more source
Circulating LPS from gut microbiota leverages stenosis-induced deep vein thrombosis in mice
Objective and design An accumulating body of evidence has shown that gut microbiota is involved in regulating inflammation; however, it remains undetermined if and how gut microbiota plays an important role in modulating deep venous thrombosis (DVT ...
Cheng Liu+9 more
doaj +1 more source
Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]
During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Becker, Bernhard F.+7 more
core +1 more source
An in vitro study of the adhesion of blood platelets onto vascular catheters. Part I [PDF]
The adhesion of human blood platelets onto vascular catheters was studied using a specially designed perfusion chamber. Polyurethane catheters were exposed to citrated human blood for different periods (up to 20 min) and at different wall shear rates ...
Aarts, P.A.M.M.+5 more
core +8 more sources
A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence
Understanding the mechanisms guiding interneuron development is a central aspect of the current research on cortical/hippocampal interneurons, which is highly relevant to brain function and pathology.
Sira A. Franchi+8 more
doaj +1 more source
Thrombomodulin is a molecule with anti-coagulant and anti-inflammatory properties. Recently, thrombomodulin was reported to be able to bind extracellular matrix proteins, such as fibronectin and collagen; however, whether thrombomodulin regulates the ...
Eiji Kawamoto+16 more
doaj +1 more source
Measuring cell adhesion forces with the atomic force microscope at the molecular level [PDF]
In the past 25 years many techniques have been developed to characterize cell adhesion and to quantify adhesion forces. Atomic force microscopy (AFM) has been used to measure forces in the pico-newton range, an experimental technique known as force ...
Benoit, M., Gaub, H. E.
core +1 more source
FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez+2 more
doaj +1 more source
Tribo-electric Charging and Adhesion of Cellulose Ethers and their Mixtures with Flurbiprofen [PDF]
The pervasiveness of tribo-electric charge during pharmaceutical processing can lead to the exacerbation of a range of problems including segregation, content heterogeneity and particle surface adhesion.
Conway, Barbara R.+2 more
core +1 more source
CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment
The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high speed, sensitivity and specificity. T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...
Philippe Robert+3 more
doaj +1 more source