Results 21 to 30 of about 2,324,065 (396)

Twin disc assessment of wheel/rail adhesion [PDF]

, 2008
Loss of adhesion between a railway wheel and the track has implications for both braking and traction. Poor adhesion in braking is a safety issue as it leads to extended stopping distances. In traction, it is a performance issue as it may lead to reduced
Gallardo-Hernandez, E.A., Lewis, R.
core   +1 more source

Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research

Open Biology, 2021
How do cells process environmental cues to make decisions? This simple question is still generating much experimental and theoretical work, at the border of physics, chemistry and biology, with strong implications in medicine.
Pierre-Henri Puech, Pierre Bongrand
doaj   +1 more source

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

Frontiers in Cell and Developmental Biology, 2020
Integrins are transmembrane proteins that mediate cellular adhesion and migration to neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse physiological and pathological pathways.
Eun Jeong Park, Phyoe Kyawe Myint, Atsushi Ito, Atsushi Ito, Michael G. Appiah, Samuel Darkwah, Eiji Kawamoto, Eiji Kawamoto, Motomu Shimaoka   +8 more
doaj   +1 more source

Nucleation of membrane adhesions [PDF]

, 2008
Recent experimental and theoretical studies of biomimetic membrane adhesions [Bruinsma et al., Phys. Rev. E 61, 4253 (2000); Boulbitch et al., Biophys. J.
Wang, Zhen-Gang, Zhang, Cheng-Zhong
core   +1 more source

Circulating LPS from gut microbiota leverages stenosis-induced deep vein thrombosis in mice

Thrombosis Journal, 2023
Objective and design An accumulating body of evidence has shown that gut microbiota is involved in regulating inflammation; however, it remains undetermined if and how gut microbiota plays an important role in modulating deep venous thrombosis (DVT ...
Cheng Liu, Ying Zhou, Huihui Gao, Zeping Zhang, Yu Zhou, Zifeng Xu, Chenhong Zhang, Zhen Xu, Huajun Zheng, Yan-Qing Ma   +9 more
doaj   +1 more source

A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence

Frontiers in Cellular Neuroscience, 2018
Understanding the mechanisms guiding interneuron development is a central aspect of the current research on cortical/hippocampal interneurons, which is highly relevant to brain function and pathology.
Sira A. Franchi, Romina Macco, Veronica Astro, Diletta Tonoli, Elisa Savino, Flavia Valtorta, Kristyna Sala, Martina Botta, Ivan de Curtis   +8 more
doaj   +1 more source

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

Biomedicines, 2021
Thrombomodulin is a molecule with anti-coagulant and anti-inflammatory properties. Recently, thrombomodulin was reported to be able to bind extracellular matrix proteins, such as fibronectin and collagen; however, whether thrombomodulin regulates the ...
Eiji Kawamoto, Nodoka Nago, Takayuki Okamoto, Arong Gaowa, Asami Masui-Ito, Yuichi Akama, Samuel Darkwah, Michael Gyasi Appiah, Phyoe Kyawe Myint, Gideon Obeng, Atsushi Ito, Siqingaowa Caidengbate, Ryo Esumi, Takanori Yamaguchi, Eun Jeong Park, Hiroshi Imai, Motomu Shimaoka   +16 more
doaj   +1 more source

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Biomolecules, 2020
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez, Pilar López Navajas, Daniel Lietha   +2 more
doaj   +1 more source

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

Cells, 2021
The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high speed, sensitivity and specificity. T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...
Philippe Robert, Laurent Limozin, P. Anton van der Merwe, Pierre Bongrand   +3 more
doaj   +1 more source

Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis

Biomedicines, 2019
Sepsis is a systemically dysregulated inflammatory syndrome, in which dendritic cells (DCs) play a critical role in coordinating aberrant immunity. The aim of this study is to shed light on the differential roles played by systemic versus mucosal DCs in ...
Samuel Darkwah, Nodoka Nago, Michael G. Appiah, Phyoe Kyawe Myint, Eiji Kawamoto, Motomu Shimaoka, Eun Jeong Park   +6 more
doaj   +1 more source