Results 31 to 40 of about 64,361 (232)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Reconsiderations on Adhesion Control for Locomotive HXD1C and HXD1

机车电传动, 2014
Adhesion control condition of locomotive HXD1C and HXD1 was introduced. For the traction demand of electric locomotive HXD1C and HXD1, corresponding improvement of adhesion utilization control software was proposed.
WU Xin-hong, GAO Shou-cong, ZHANG Jian-bai, ZENG Yun, ZHANG Zheng-fang, DING Pei-yi   +5 more
doaj  

Adhesion Control of High-Speed Train Based on Improved Nonlinear Kalman Filter

Applied Sciences
In the operation of high-speed trains, the effective transmission of traction force heavily relies on the adhesion between the wheel and the rail. Excessive traction or braking force may exceed the adhesion limit, causing wheel creep or slide, which ...
Haotian Gan, Song Wang, Junqi Lu, Haoran Ou   +3 more
doaj   +1 more source

Utilization of xylitol as a preventive substance in dentistry

Brazilian Journal of Oral Sciences, 2015
Dental caries is an infectious-contagious disease of multifactorial origin, which requires interference in one or more of its etiologic factors for prevention. Within this context, the utilization of xylitol is highlighted, which was initially studied as
José Roberto de Magalhães Bastos, Lucilene Sanches Cirilo Cunha, Ricardo Henrique Alves Silva, Fabíola Elias, Hilton José Gurgel Rodrigues   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Adhesion Control Method for EMU

Chengshi guidao jiaotong yanjiu
Objective Given the high operating speeds, minimal residual acceleration margin, and open-air track conditions of EMU (electric multiple units), as well as the deficiencies in conventional combination correction methods such as poor accuracy in criterion
MA Fayun, ZHANG Jiabo, MIAO Cunxu, LIN Xianqi, YANG Qilin, ZENG Fanfei   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Comparison on Adhesion Control Performance for the New Generation ElectricLocomotive Made in China and Toshiba 19E Electric Locomotive Made in Japan

机车电传动, 2016
The adhesion control technical level of the new generation electric locomotive made in China represented by Shenhua and20E locomotive for South Africa was introduced.
QIU Zirong, ZHANG Zhengfang, LIANG Xingyuan   +2 more
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source