Results 71 to 80 of about 408,963 (292)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Fracture mechanics-based design and analysis of structural adhesive joints
, 2023 This chapter presents fracture mechanics based analysis and design of adhesively bonded structures. Common configurations and stress analysis characteristics of structural adhesive joints are introduced. Stress analysis and energy release rate based on a
Luo, Q, Ji, J
core +1 more source
Frontiers in Veterinary Science, 2020 Mandibular fracture repair is complicated by limited availability of bone as well as the presence of the neurovascular bundle and an abundance of tooth roots.
Alexander T. Geddes +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Fracture mechanics of adhesive joints
, 2022 S.135-166This chapter summarizes the basic principles and definitions of fracture mechanics and gives an overview of its application to adhesive bonding. From the macroscopic point of view the stress intensity factor or the equivalent energy release rate
Brede, Markus
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Modeling of modulus graded axisymmetric adhesive joints
This study presents a refined theoretical framework for the stress analysis of modulus graded axisymmetric adhesive joints which takes into account the radial stresses in the bonded assembly.
Kumar, Shanmugan, Scanlan, J.P.
core +2 more sources
Biomaterial Investigations in DentistryLaser-assisted endodontic treatments have gained popularity over the last decade. This study evaluated the flexural strength (FS), fatigue resistance, and surface characteristics of root dentine after laser-assisted endodontic protocols.
Jaana Hannele Sippus +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Langmuir, 2006 The adhesion of microcapsules to an attractive contact potential is studied theoretically. The axisymmetric shape equations are solved numerically. Beyond a universal threshold strength of the potential, the contact radius increases like a square root of the strength.
Graf, Peter +2 more
openaire +3 more sources