Results 171 to 180 of about 272,112 (304)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A bioabsorbable adhesive wrap for sutureless arterial repair: Initial development and preclinical testing in a rat model. [PDF]

J Trauma Acute Care Surg
Nithianandam P, Hesek A, Steinmetz M, Mills J, Liu R, Corao-Uribe D, Shaffer T, Blauvelt DG, Wilmington, Delaware.   +9 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

In Vitro Evaluation of an Adhesive Hydrogel-Based Chondrocyte Carrier for Enhanced Therapeutic Delivery. [PDF]

Macromol Biosci
Karami P, Laurent A, Philippe V, Applegate LA, Pioletti DP, Martin R.   +5 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Bone adhesive with temporally-synchronized degradation for enhanced osteointegration. [PDF]

Bone Res
Gu JT, Li ZT, Wang YZ, Hao DX, Dang GP, Cao XQ, Tay FR, Chen JH, Aparicio C, Jiao K, Niu LN.   +10 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Pinecone-Inspired Water-Responsive Curling Adhesive Conduit for Peripheral Nerve Repair. [PDF]

Cyborg Bionic Syst
Guo X, Li J, Xu H, Long S, Li J, Wang A, Liu W, Zhang F, Li Z, Luo F, Li J, Wang Y, Tan H, Lan T.   +13 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Ammonium Bisulfite and Urea-Metabisulfite as Formaldehyde Scavengers in Low-Molar-Ratio Urea-Formaldehyde Resin for Medium-Density Fiberboard: Curing Behavior and Panel Performance. [PDF]

Polymers (Basel)
Dudeva V, Ivanov G, Savov V, Antov P, Ninikas K, Petrin S, Kostadinova-Slaveva A.   +6 more
europepmc   +1 more source