Results 141 to 150 of about 76,948 (302)

Clinical Relevance of Adipokines

Diabetes & Metabolism Journal, 2012
The incidence of obesity has increased dramatically during recent decades. Obesity increases the risk for metabolic and cardiovascular diseases and may therefore contribute to premature death. With increasing fat mass, secretion of adipose tissue derived bioactive molecules (adipokines) changes towards a pro-inflammatory, diabetogenic and atherogenic ...
openaire   +3 more sources

Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population

Allergy, EarlyView.
The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard, Ralph Heijmans, Virgil A. S. H. Dalm, Silvan Licher, Jan Nouta, Steinar Gijze, David Falck, P. Martin van Hagen, Robin Peeters, Manfred Wuhrer, Layal Chaker   +10 more
wiley   +1 more source

Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge

Biomolecules
Cardiometabolic risk and associated dysfunctions contribute largely to the recent rise in mortality globally. Advancements in multi-omics in recent years promise a better understanding of potential biomarkers that enable an early diagnosis of ...
Sayantap Datta, Saisudha Koka, Krishna M. Boini   +2 more
doaj   +1 more source

Fat reduction mediates the efficacy of intensive lifestyle interventions on fertility‐sparing treatment in overweight patients with endometrial cancer and intraepithelial neoplasia

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Intensive lifestyle interventions‐based weight management targeting fat reduction may enhance fertility‐sparing treatment outcomes in overweight patients with endometrial cancer or its precursor. Our findings advocate the integration of body composition‐guided weight management into standardized protocols.
Sijia Liu, Li Li, Pengfei Wu, Lulu Wang, Qujia Gama, Manrong Wang, Jinyu Zhang, Liping Jin, Xuezhen Luo, Weiwei Shan, Bingyi Yang   +10 more
wiley   +1 more source

The Impact of Obesity on Durable Left Ventricular Assist Device Implantation: A Systematic Review and Meta‐Analysis

Artificial Organs, EarlyView.
14 100 LVAD patients across 21 studies were analyzed. Findings indicated that obese LVAD recipients had lower short‐term mortality and higher risk of infection, thrombosis and right heart failure. There was no difference in long‐term survival between obese and non‐obese patients.
Hugh Jacobs, Olivia Frost, Arian Arjomandi Rad, Wing Kiu Chou, Sadeq Al‐Saegh, Alina Zubarevich, Alexander Weymann, Arjang Ruhparwar, Lukman Amanov, Peyman Sardari Nia, Antonios Kourliouros, Thanos Athanasiou   +11 more
wiley   +1 more source

Sarcopenia Is Associated With Mortality and Progression of Cirrhosis in Decompensated but Not Compensated Disease—A Multicentre Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective cohort of 1,624 adults with cirrhosis, sarcopenia was independently associated with unplanned hospitalization, death, and cirrhosis progression (or death) in patients with decompensated disease. In compensated cirrhosis, sarcopenia was associated only with a higher risk of unplanned hospitalization.
Puneeta Tandon, Sarah Wang, Moon Young Kim, Bart Van Hoek, Daphne Bot, Jeroen L. A. van Vugt, Berend Beumer, Jan Ijzermans, Sunil Taneja, Ajay Duseja, Surender Singh, Maryam Ebadi, Aldo J. Montano‐Loza   +12 more
wiley   +1 more source

Circulating levels of insulin‐like growth factor I (IGF‐I) and risk of multiple myeloma: An observational and Mendelian randomisation study

British Journal of Haematology, EarlyView.
Summary Evidence for an association between insulin‐like growth factors (IGF) and multiple myeloma (MM) is inconsistent. We examined total IGF‐I concentrations and risk of MM by combining baseline serological data among UK Biobank participants (n = 444 187; 732 incident MM) with a two‐sample Mendelian randomisation (MR) analysis using identified ...
Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa Clay‐Gilmour, Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qing Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Shaji K. Kumar, Celine M. Vachon, Anne J. Novak, Thomas M. Habermann, Brian K. Link, Gilles Salles, Herve Ghesquieres, Paige M. Bracci, Elizabeth Holly, Rosalie G. Griffin, Michelle A. T. Hildebrandt, Roel C. H. Vermeulen, P. Martijn Kolijn, Henrik Hjalgrim, Karin Ekström Smedby, Harindra Jayasekara, Simon Cheah, Alain Monnereau, Yu Chen, Alan Arslan, Yawei Zhang, Nicola J. Camp, Douglas W. Sborov, Afaf E. G. Osman, Elad Ziv, Immaculata De Vivo, Vijai Joseph, Lauren R. Teras, Alpa V. Patel, Eleanor Kane, Claire M. Vajdic, Adrien Guilloteau, Pierluigi Cocco, Laia Alemany, Juan Sainz, James McKay, Brenda M. Birmann, Delphine Casabonne   +56 more
wiley   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation [PDF]

, 2016
Obesity is recognized as an important risk factor for the development of many chronic diseases such as hypertension, Type 2 diabetes mellitus (T2DM) cardiovascular disease, cancer, renal disease, neurologic dysfunction, metabolic syndrome and asthma (3 ...
Bradley, Jennifer L
core   +1 more source

Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues, Minjin Lee, Yejee Lim, Jennie Young, Brendon Chung, Susan Phillips, Theodore P. Ciaraldi, Young‐Bum Kim   +7 more
wiley   +1 more source