Results 131 to 140 of about 519,569 (305)

Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells

International Journal of Nanomedicine
Ruoyu Zhao,1 Lei Ma,2 Joan Li,3 Sen Liu,1 Dalong Yang,2 Guobin Liu,1 Sidong Yang4 1Department of Orthopedic Surgery, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Spine Surgery, Hebei ...
Zhao R, Ma L, Li J, Liu S, Yang D, Liu G, Yang S   +6 more
doaj  

Adiposity [PDF]

Postgraduate Medical Journal, 1946
openaire   +4 more sources

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Modulation of adipose inflammation and mitochondrial pathways by a yeast-derived β-1,3/1,6-glucan and vitamin complex: an open-label pilot study of Lalmin® immune pro in older overweight adults

Frontiers in Nutrition
Chronic low-grade inflammation and mitochondrial dysfunction contribute to age- and obesity-related disease, yet few nutritional interventions have been shown to impact both processes.
Jack Pritchard, Lauren Struszczak, Cealan Henry, Celeste Lugtmeijer, Joanna Bowtell, Mary O’Leary   +5 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Bovine adipose mitochondrial adaptation and a potential lactate–ketone toggle in early lactation

Frontiers in Veterinary Science
The periparturient period creates an intense energy demand due to the onset of lactation, which requires substantial glucose for milk synthesis, particularly in high producing cows, contributing to a high incidence of postpartum metabolic disease.
Nial J. O’Boyle, Miguel Chirivi, Ursula Abou-Rjeileh, David Salcedo-Tacuma, José M. dos Santos Neto, Crystal Prom, Jair Parales-Girón, Adam L. Lock, Reinhard Stöger, Lisa Chakrabarti, G. Andres Contreras   +10 more
doaj   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

“Immunohistochemical Localization of Leptin in Adipose Tissues” in coll.

, 1997
“Immunohistochemical Localization of Leptin in Adipose Tissues” in coll. R. DeMatteis, M.C. Zingaretti and J. Himms-Hagen. In: Leptin the voice of Adipose Tissue. Ed. by W.F. Blum, W.
M. C. ZINGARETTI AND J. HIMMS HAGEN, R. DEMATTEIS, CINTI, Saverio   +2 more
core  

The interactions between autophagy and immune in the liver-adipose-ovary circuit of polycystic ovary syndrome

Frontiers in Immunology
Polycystic ovary syndrome (PCOS) is a common reproductive, endocrine, and metabolic disorder in women of reproductive age, characterized by hyperandrogenemia, insulin resistance, and ovulatory dysfunction. Autophagy, a key cellular homeostasis mechanism,
Guofeng Nie, Muxuan Liu, Luxu Yang, Chanyu Li, Chenzhao Qu, Jing Wang, Juanjuan Mei, Yanlin Wang, Lei Han, Xinwei Zhang, Quanmin Wang   +10 more
doaj   +1 more source

Adiposity-Sensitive and Adiposity-Resistant Hypertension? [PDF]

American Journal of Hypertension, 2008
openaire   +2 more sources