Results 171 to 180 of about 5,616,381 (302)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Engineering 3D adipose cell models by support bath bioprinting of mature adipocytes in gellan gum hydrogels. [PDF]

Eng Life Sci
Nowakowski S, Albrecht FB, Kluger PJ.
europepmc   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice. [PDF]

Biol Sex Differ
Zhao Y, Liu R, Ng JP, Yu S, Ahn IS, Diamante G, Zhang G, Thorson A, Schaefers KP, Stafford JM, Yang X.   +10 more
europepmc   +1 more source

The Anti-Aging Effects of Adipose-Derived Mesenchymal Stem Cell Exosomes on Skin and Their Potential for Personalized Skincare Applications [PDF]

Yan-Xiu Jin,1 Guang-Zhen Jin2 1School of Tourism Management, Yanbian University, Yanji, People’s Republic of China; 2Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South KoreaCorrespondence: Guang-Zhen Jin, Institute of Tissue
Jin YX, Jin GZ
core  

adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue

We developed the Adipose Tissue Knowledge Portal by centralizing previously dispersed datasets, integrating clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men.
Ståhl, Patrik,, Ryden, Mikael,, Zhong, Jiawei,, Massier, Lucas,, Bhalla, Nayanika,, Mejhert, Niklas,, Pietiläinen, Kirsi, Frendo-Cumbo, Scott, Hoffmann, Anne, Krahmer, Natalie, Arner, Peter, Ghosh, Adhideb, Klingelhuber, Felix, Tönjes, Anke, Massier, Lucas, Zareifi, D, Nankam, PAN, Blüher, Matthias, Hansen, M, de Castro Barbosa, Thais, Bhalla, N, Bhalla, Nayanika, Keller, Maria, Wolfrum, Christian, Heinonen, Sini, Cordeddu, Lina, Böttcher, Yvonne, Zhong, J,, Klingelhuber, F, Zareifi, Danae, Ståhl, Patrik, Hansen, Mattias, Kerr, Alastair, Weinbrenner, Sophie, Langin, Dominique, Rydén, Mikael, John, Dorit, Kovacs, Peter, Zhong, Jiawei, Nono Nankam, Pamela, Weinbrenner, S, Cordeddu, L, Mejhert, Niklas, Frendo-Cumbo, S, Barbosa, TDC, Dahlman, Ingrid, Muniandy, Maheswary   +46 more
core   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Vascularized skin tissue models featuring adipose cell spheroid-laden GelMA hydrogels. [PDF]

Mater Today Bio
Lee D, Lee S, Lee J, Kim D, Kwon H, Ahn J, Lim H, Lee JJ, Shin H, Park SA.   +9 more
europepmc   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source