Results 211 to 220 of about 5,616,381 (302)

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Exosome-mediated immunomodulatory and barrier-protective responses of adipose-derived mesenchymal stem cells in oleic acid-induced acute lung injury. [PDF]

Acta Cir Bras
Ayar G, Ince B, Buyukafsar K, Bahar L, Onsoz E, Maytalman E, Koksel MO.   +6 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Transcriptome and Functional Analysis Uncover the Role of ADCY5 in Bovine Adipogenesis. [PDF]

Anim Genet
Wei X, Shan X, Yang L, Zhao X, Ma Y, Zhang P, Xu Y, Hao R.   +7 more
europepmc   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Female-specific reliance on endothelial FoxO1 governs vascular resilience and metabolic adaptation to obesity. [PDF]

Angiogenesis
Pislaru A, Roudier E, Rezvan O, Breadmore C, Fathi M, Nader G, AlZaim I, Nwadozi E, Lee G, Yavari E, Fawzy A, Rullman E, Kalucka J, Gustafsson T, Rudnicki M, Haas TL.   +15 more
europepmc   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

The Adipovascular Unit in Lipedema: A Framework for Regional Adipose Tissue Dysregulation. [PDF]

Cells
Faulhaber J, Hanke CW, Barsch M, Sandhofer M.   +3 more
europepmc   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice. [PDF]

Diabetes
Dong G, Spyropoulos G, Adak S, Zhang Q, Zhang W, Speck SL, Maimaituxun G, Kleiboeker B, Lodhi IJ, Wei X, Semenkovich CF.   +10 more
europepmc   +1 more source