Results 211 to 220 of about 13,270,977 (291)

Integrative genomic SEM analysis of shared genetic architecture and candidate genes for insulin resistance-related metabolic traits. [PDF]

PLoS One
Li S, Liang Y, Zhu G, Wu L, Li H, Li Y, Chen Q.   +6 more
europepmc   +1 more source

A diarylheptanoid from <i>Alpinia officinarum</i> ameliorates insulin resistance in 3T3-L1 adipocytes and db/db mice through modulation of PPARγ/PI3K/AKT signaling pathway. [PDF]

Front Pharmacol
Chen Q, Wang Y, Jiang J, He P, Xie Z, Zhou M, Deng Z, Zhang J, Zhang X, Yin Q.   +9 more
europepmc   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging

Arthritis &Rheumatology, EarlyView.
Objective The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing in vastus lateralis muscle, resulting in 523 participants (56% female).
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Effects of ATP Citrate Lyase and Adipose Differentiation-Related Protein Gene Polymorphisms on Adipose Deposition and Meat Quality Traits in Pigs

Journal of Animal and Veterinary Advances, 2011
Zhu-Qing Ren, Yuan-Zhu Xiong, Chang-Yan Deng, Si-Wen Jiang   +3 more
openaire   +1 more source

Adipose-derived CLEC3B promotes osteogenesis through a CLEC3B-IGFBP4-related paracrine axis associated with mitochondrial adaptation in postmenopausal osteoporosis. [PDF]

Cell Biol Toxicol
Xia Z, Wei L, Ji J, Wu S, Sun Y, Zong G, Li X, Ye Y, Zhang Y, Huang D.   +9 more
europepmc   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Extracellular Vesicle-Mediated Local and Systemic Communication in Metabolic Diseases. [PDF]

Int J Mol Sci
Fan RP, Gou LP, Ma JF, Yang JM, Wood JI, Zhang RN, Fu XH, Tong NW.   +7 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity. [PDF]

Int J Mol Sci
Zhu A, Zhou Y, Ren K, Sun C.
europepmc   +1 more source