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Regulation of Adipocyte Differentiation via MicroRNAs [PDF]

Endocrinology and Metabolism, 2014
Adipocyte differentiation, termed adipogenesis, is a complicated process in which pluripotent mesenchymal stem cells differentiate into mature adipocytes. The process of adipocyte differentiation is tightly regulated by a number of transcription factors,
You Hwa Son, Sojeong Ka, A Young Kim, Jae Bum Kim   +3 more
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Targeting adipocyte differentiation with CRT0066101: activation of AMPK signaling in 3T3-L1 cells [PDF]

Frontiers in Pharmacology
IntroductionObesity is characterized by excessive fat accumulation resulting from adipocyte hypertrophy and hyperplasia, with adipocyte differentiation being a central process driving these changes.MethodsThe anti-adipogenic effects of CRT0066101 (CRT ...
Jinque Luo, Jinque Luo, Ling Wang, Ling Wang, Li Zhang, Li Zhang, Wenyu Tang, Meijing Deng, Meijing Deng, Yuxin Shi, Kun Xu, Qingjun Wu, Jieyang Zhao, Jinghuan Zhang, Xin Li, Xin Li   +15 more
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Involvement of long non-coding RNA (lncRNA) MALAT1 in shear stress regulated adipocyte differentiation [PDF]

Frontiers in Bioengineering and Biotechnology
Adipocyte differentiation plays an important role in bone remodeling due to secretory factors that can directly modulate osteoblast and osteoclast, thus affecting overall bone mass and skeletal integrity.
Justin Caron, Marjan Ghanbariabdolmaleki, Madison Marino, Chong Qiu, Bo Wang, Michael Mak, Shue Wang   +6 more
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The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation [PDF]

Molecular Metabolism
Objective: Adipocyte differentiation is critical for the metabolically protective expansion of adipose tissue. Impaired differentiation drives lipodystrophy and pathologic tissue remodeling, major contributors to cardiometabolic diseases.
Yang Chen, Lin Liu, Ryan P. Calhoun, Lan Cheng, David Steger, Patrick Seale   +5 more
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Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to metabolic dysfunction-associated steatotic liver disease [PDF]

Nature Communications
The mechanisms connecting the human fat depots, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), to metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive.
Kyla Z. Gelev, Seung Hyuk T. Lee, Marcus Alvarez, Rosellina M. Mancina, Federica Tavaglione, Oveis Jamialahmadi, Umberto Vespasiani-Gentilucci, Asha Kar, Zitian Wang, Dorota Kaminska, Minna U. Kaikkonen, Ville Männistö, Sini Heinonen, Tuure Saarinen, Anne Juuti, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Stefano Romeo, Päivi Pajukanta   +18 more
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C/EBPα plays a critical role in adipocyte differentiation and obesity [PDF]

Frontiers in Molecular Biosciences
CCAAT/enhancer-binding protein alpha (C/EBPα), a key member of the transcription factor family, inhibits proliferation and plays a central role in adipocyte differentiation, hematopoiesis, and other cellular processes.
Xiao Li, Hui Li, Fang Peng, Jianhua Li, Xiaoli Hou, Shaoping Ji, Shaoping Ji   +6 more
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MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis

Journal of Animal Science and Biotechnology, 2021
Background A considerable number of muscle development-related genes were differentially expressed in the early stage of avian adipocyte differentiation. However, the functions of them in adipocyte differentiation remain largely known. In this study, the
Zheng Wang, Qiangsen Zhao, Xiaoqin Li, Zhongtao Yin, Sirui Chen, Sen Wu, Ning Yang, Zhuocheng Hou   +7 more
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Immature adipocyte‐derived exosomes inhibit expression of muscle differentiation markers

FEBS Open Bio, 2021
Exosomes are released from a variety of cells to communicate with recipient cells. Exosomes contain microRNAs (miRNAs), which are noncoding RNAs that suppress target genes.
Koichi Ojima, Susumu Muroya, Hiromu Wada, Kotaro Ogawa, Mika Oe, Koichi Takimoto, Takanori Nishimura   +6 more
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Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet

Cell Death and Disease, 2022
Obesity is a risk factor for many chronic diseases, and is associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia and cardiovascular diseases.
Shuang Kan, Rong Li, Yanhui Tan, Fang Yang, Shaohua Xu, Lingzhu Wang, Lijun Zhang, Xuchen Sun, Xuanming Chen, Yuting Yang, Wei Shu, Huaibin Wan, Zheng-Feng Chen, Hong Liang, Ming Chen   +14 more
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Mitochondrial reactive oxygen species regulate adipocyte differentiation of mesenchymal stem cells in hematopoietic stress induced by arabinosylcytosine. [PDF]

PLoS ONE, 2015
The increase in adipocytes induced by chemotherapeutic drugs may play a negative role in hematopoietic recovery. However, the mechanism underlying adipocyte differentiation of mesenchymal stem cells (MSCs) in hematopoietic stress is still unknown. Hence,
Weimin Wang, Yao Zhang, Wenyi Lu, Kaiyan Liu   +3 more
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