Results 11 to 20 of about 118,942 (299)

E2Fs Regulate Adipocyte Differentiation [PDF]

Developmental Cell, 2002
When preadipocytes reenter the cell cycle, PPAR gamma expression is induced, coincident with an increase in DNA synthesis, suggesting the involvement of the E2F family of cell cycle regulators. We show here that E2F1 induces PPAR gamma transcription during clonal expansion, whereas E2F4 represses PPARg amma expression during terminal adipocyte ...
Fajas, Lluis, Landsberg, Rebecca L., Huss-Garcia, Yolande, Sardet, Claude, Lees, Jacqueline A., Auwerx, Johan   +5 more
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Transcriptional Networks Controlling Adipocyte Differentiation [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2011
Adipocyte differentiation is regulated by a complex cascade of signals that drive the transcriptional reprogramming of the fibroblastic precursors. Genome-wide analyses of chromatin accessibility and binding of adipogenic transcription factors make it possible to generate "snapshots" of the transcription factor networks operating at specific time ...
Siersbæk, R, Mandrup, Susanne
openaire   +3 more sources

Conditioned medium from human tonsil-derived mesenchymal stem cells inhibits glucocorticoid-induced adipocyte differentiation

PLoS ONE, 2022
Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu   +4 more
doaj   +2 more sources

Mitochondrial reactive oxygen species regulate adipocyte differentiation of mesenchymal stem cells in hematopoietic stress induced by arabinosylcytosine. [PDF]

PLoS ONE, 2015
The increase in adipocytes induced by chemotherapeutic drugs may play a negative role in hematopoietic recovery. However, the mechanism underlying adipocyte differentiation of mesenchymal stem cells (MSCs) in hematopoietic stress is still unknown. Hence,
Weimin Wang, Yao Zhang, Wenyi Lu, Kaiyan Liu   +3 more
doaj   +1 more source

Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]

, 2020
Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R., Bermúdez- Peña, M. Carmen, Jurek, Sandra, Kolisek, Martin, Sandhu, Mansur A., Sponder, Gerhard, Trappe, Susanne   +6 more
core   +1 more source

MicroRNA-143 Regulates Adipocyte Differentiation [PDF]

Journal of Biological Chemistry, 2004
MicroRNAs (miRNAs) are endogenously expressed 20-24 nucleotide RNAs thought to repress protein translation through binding to a target mRNA (1-3). Only a few of the more than 250 predicted human miRNAs have been assigned any biological function. In an effort to uncover miRNAs important during adipocyte differentiation, antisense oligonucleotides (ASOs)
Christine, Esau, Xiaolin, Kang, Eigen, Peralta, Elaine, Hanson, Eric G, Marcusson, Lingamanaidu V, Ravichandran, Yingqing, Sun, Seongjoon, Koo, Ranjan J, Perera, Ravi, Jain, Nicholas M, Dean, Susan M, Freier, C Frank, Bennett, Bridget, Lollo, Richard, Griffey   +14 more
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A Transcriptomic Analysis Reveals Novel Patterns of Gene Expression During 3T3-L1 Adipocyte Differentiation

Frontiers in Molecular Biosciences, 2020
BackgroundObesity is characterized by increased adipose tissue mass that results from increased fat cell size (hypertrophy) and number (hyperplasia). The molecular mechanisms that govern the regulation and differentiation of adipocytes play a critical ...
Wuping Sun, Zhijian Yu, Shaomin Yang, Changyu Jiang, Yanbo Kou, Lizu Xiao, Shuo Tang, Tao Zhu   +7 more
doaj   +1 more source

Estrogen Sulfotransferase Inhibits Adipocyte Differentiation [PDF]

Molecular Endocrinology, 2011
The estrogen sulfotransferase (EST) is a phase II drug-metabolizing enzyme known to catalyze the sulfoconjugation of estrogens. EST is highly expressed in the white adipose tissue of male mice, but the role of EST in the development and function of adipocytes remains largely unknown.
Taira, Wada, Chibueze A, Ihunnah, Jie, Gao, Xiaojuan, Chai, Su, Zeng, Brian J, Philips, J Peter, Rubin, Kacey G, Marra, Wen, Xie   +8 more
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Lithium inhibits brown adipocyte differentiation [PDF]

FEBS Letters, 2005
Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose‐dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation.
Rodrı́guez de la Concepción, Maria Luisa, Yubero, Pilar, Iglesias, Roser, Giralt, Marta, Villarroya, Francesc   +4 more
openaire   +2 more sources

Actin depolymerization enhances adipogenic differentiation in human stromal stem cells

Stem Cell Research, 2018
Human stromal stem cells (hMSCs) differentiate into adipocytes that play a role in skeletal tissue homeostasis and whole body energy metabolism. During adipocyte differentiation, hMSCs exhibit significant changes in cell morphology suggesting changes in ...
Li Chen, Huimin Hu, Weimin Qiu, Kaikai Shi, Moustapha Kassem   +4 more
doaj   +1 more source