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Silencing of Homeodomain-Interacting Protein Kinase 2 (HIPK2) Induces Anti-Adipogenic Effects in 3T3-L1 Adipocytes [PDF]

Current Issues in Molecular Biology
Homeodomain-interacting protein kinase 2 (HIPK2) is an important regulator of various transcription factors and cofactors, which are involved in cell growth, cell death, and embryonic development.
Anil Kumar Yadav, Nivethasri Lakshmana Perumal, Gi-Young Park, Byeong-Churl Jang   +3 more
doaj   +2 more sources

Effects of Bacillus Subtilis-Fermented White Sword Bean Extract on Adipogenesis and Lipolysis of 3T3-L1 Adipocytes

Foods, 2021
To investigate the adipogenesis and lipolysis effects of the Bacillus subtilis-fermented white sword bean extract (FWSBE) on 3T3-L1 adipocytes, we treated 3T3-L1 preadipocytes before and after differentiation with FWSBE and measured triglyceride, free ...
Yujeong Choi, Da-Som Kim, Min-Chul Lee, Seulgi Park, Joo-Won Lee, Ae-Son Om   +5 more
doaj   +1 more source

Type III Collagen is Required for Adipogenesis and Actin Stress Fibre Formation in 3T3-L1 Preadipocytes

Biomolecules, 2021
GPR56 is required for the adipogenesis of preadipocytes, and the role of one of its ligands, type III collagen (ColIII), was investigated here. ColIII expression was examined by reverse transcription quantitative polymerase chain reaction, immunoblotting
Mohammad Al Hasan, Patricia E. Martin, Xinhua Shu, Steven Patterson, Chris Bartholomew   +4 more
doaj   +1 more source

MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway

Lipids in Health and Disease, 2022
Background MicroRNAs (MiRNAs) are known to participate in preadipocyte differentiation, but the manner in which miR-146a-5p participates in this process remains unclear.
Yifen Wang, Jie Zhang, Xueru Chu, Mengke Wang, Yongning Xin, Shousheng Liu   +5 more
doaj   +1 more source

Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells

Open Medicine, 2023
To investigate the effects of cimifugin on adipogenesis and tumor necrosis factor (TNF-α)-induced insulin resistance (IR) and inflammation in 3T3-L1 adipocytes.
Deng Xiang, Liu Zhenmin, Han Siqi
doaj   +1 more source

A novel 3T3-L1 preadipocyte variant that expresses PPARγ2 and RXRα but does not undergo differentiation

Journal of Lipid Research, 1998
This report describes a novel adipocyte-like cell line termed 3T3-L1/RB1 that was derived from preadipocyte cell line, 3T3-L1. The 3T3-L1/RB1 cells continued to divide after reaching confluence, formed foci, and constitutively expressed a low level of ...
Rebecca A. Baillie, Xiaoming Sha, Philippe Thuillier, Steven D. Clarke   +3 more
doaj   +1 more source

Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells

FEBS Open Bio, 2020
Dysregulation of adipocyte differentiation and dysfunction play key roles in the pathogenesis of obesity and associated disorders such as diabetes and metabolic syndrome, and as such, a better understanding of the molecular mechanism of adipogenesis may ...
Tomiyasu Murata, Masayoshi Yamaguchi, Susumu Kohno, Chiaki Takahashi, Watanabe Risa, Kanna Hatori, Kiyomi Hikita, Norio Kaneda   +7 more
doaj   +1 more source

Matrigel® enhances 3T3-L1 cell differentiation

Adipocyte, 2021
Culturing cells on bio-gels are believed to provide a more in vivo-like extracellular matrix. 3T3-L1 cells cultured on Matrigel® significantly alteregd their proliferation and differentiation as compared to growth on tissue culture-coated polystyrene ...
Chitmandeep Josan, Sachin Kakar, Sandeep Raha   +2 more
doaj   +1 more source

Evaluating the feasibility of Cas9 overexpression in 3T3-L1 cells for generation of genetic knock-out adipocyte cell lines

Adipocyte, 2021
Cell lines recapitulating physiological processes can represent alternatives to animal or human studies. The 3T3-L1 cell line is used to mimic adipocyte function and differentiation. Since transfection of 3T3-L1 cells is difficult, we used a modified 3T3-
Tomás Suchý, Isabell Kaczmarek, Tomislav Maricic, Christian Zieschang, Torsten Schöneberg, Doreen Thor, Ines Liebscher   +6 more
doaj   +1 more source

Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes

BMC Research Notes, 2022
Objective The mesoderm-specific transcript (Mest) is an imprinted gene that is transcribed from the paternal allele. It is a marker of adipose tissue expansion; however, it is uncertain whether Mest expression promotes or suppresses adipogenic ...
Yoshito Kadota, Takashige Kawakami, Masao Sato, Shinya Suzuki   +3 more
doaj   +1 more source