Results 31 to 40 of about 58,354 (259)
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
MicroRNA and 3T3-L1 pre-adipocyte differentiation [PDF]
RNA, 2006 MicroRNAs (miRNAs) have been suggested to play important roles in cell proliferation, apoptosis, and differentiation. In this study, we examined miRNA expression profiles during 3T3-L1 pre-adipocyte differentiation. We constructed miRNA libraries from pre- and post-differentiated 3T3-L1 cells, and identified the expression of 77 previously reported ...
Kazuaki, Kajimoto +2 more
openaire +2 more sources
Biology, 2022 β3-adrenergic receptor (β3-AR) is expressed predominantly in mature white and brown/beige adipocytes. Although the lipolytic and thermogenic role of β3-AR in brown/beige adipocytes is well defined, the adipogenic role of β3-AR in white adipocytes remains
Amir Roshanzadeh +4 more
doaj +1 more source
Octanoate Attenuates Adipogenesis in 3T3-L1 Preadipocytes [PDF]
The Journal of Nutrition, 2002 Preadipocytes exposed to octanoate accumulate less lipid than cells exposed to long-chain fatty acids. This effect of octanoate involves significant attenuation of expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor (PPAR)gamma, steroid regulatory binding element protein (SREBP)-1c and CCAAT element ...
Jianrong, Han +7 more
openaire +2 more sources
Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by Berberine Treatment
Natural Product Communications, 2015 The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying adipocytes. Increased oxidative stress in accumulated fat was found in 3T3-L1 cells.
Shi-Fen Dong +5 more
doaj +1 more source
DMRT2 Interacts With FXR and Improves Insulin Resistance in Adipocytes and a Mouse Model
Frontiers in Endocrinology, 2022 Insulin resistance (IR) plays a critical role in cardiovascular diseases and metabolic diseases. In this study, we identified the downregulation of DMRT2 in adipose tissues from insulin-resistant subjects through bioinformatics analysis and in an insulin-
Jing Tao +11 more
doaj +1 more source
Regulation of pyruvate carboxylase in 3T3-L1 cells [PDF]
Biochemical Journal, 1995 When 3T3-L1 fibroblasts differentiate to adipocytes, the specific activity of pyruvate carboxylase (PC) increases about 25-fold in parallel with its intracellular protein concentration. The increase in PC protein concentration is accompanied by a 9-10-fold increase in the relative abundance of 4.2 kb PC mRNA measured by Northern-blot analysis using a ...
J, Zhang, W L, Xia, F, Ahmad
openaire +2 more sources
MicroRNA-125a-5p Mediates 3T3-L1 Preadipocyte Proliferation and Differentiation
Molecules, 2018 Excessive accumulation of adipose tissue is a main cause of obesity or overweight, which is significantly involved in increasing the risk of diseases. Recently, numerous studies have proved that microRNAs (miRNAs) play important roles in adipogenesis by ...
Yan Xu +12 more
doaj +1 more source
Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes
Biomolecules, 2021 The efficacy of α-cubebenol isolated from Schisandra chinensis has been studied in several diseases, including cecal ligation, puncture challenge-induced sepsis, and degranulation of neutrophils.
Su Jin Lee +7 more
doaj +1 more source
Simple Analysis of Lipid Inhibition Activity on an Adipocyte Micro-Cell Pattern Chip
Biomolecules, 2018 Polydimethyl-siloxane (PDMS) is often applied to fabricate cell chips. In this study, we fabricated an adipocyte microcell pattern chips using PDMS to analyze the inhibition activity of lipid droplets in mouse embryo fibroblast cells (3T3-L1) with anti ...
Gi Yong Kim +5 more
doaj +1 more source