Results 51 to 60 of about 235,191 (202)
Advanced Science, EarlyView.In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu +8 more
wiley +1 more source
Advanced Science, EarlyView.An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song +5 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang +12 more
wiley +1 more source
, 2013 CAR-3T3-L1 preadipocytes and adipocytes were infected with adenovirus expressing Ephrin-B1 (Ad-EfnB1) or β-galactosidase (Ad-βgal). CAR-3T3-L1 adipocytes were transfected with Ad-EfnB1 or Ad-βgal on day 7 after differentiation and cocultured with RAW264 ...
Yu Tsushima (465409) +11 more
core +1 more source
Animal Research and One Health, EarlyView.This study identified a molecule named lncRSFD, which is highly expressed in sheep adipose tissues. The lncRSFD gene generates two distinct transcript variants via alternative splicing: lncRSFD‐L and lncRSFD‐S. Functionally, lncRSFD alternative splicing (lncRSFD‐L/S) promotes the proliferation, differentiation, and lipid metabolism of adipocytes ...
Jinpeng Wang +9 more
wiley +1 more source
JMJD2B stimulates differentiation of 3T3-L1 preadipocytes.
, 2017 (A) Knockdown of JMJD2B decreased differentiation of 3T3-L1 preadipocytes. The 3T3-L1 preadipocytes were transfected with JMJD2B siRNA and differentiated in the differentiation medium for six days. The expression of JMJD2B was measured at days 0 (0d) and
Ji-Hyun Kim (326943) +2 more
core +1 more source
JSFA reports, EarlyView.Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed +5 more
wiley +1 more source
High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells. [PDF]
PLoS ONE, 2011 BACKGROUND: High density lipoprotein (HDL) was reported to decrease plasma glucose and promote insulin secretion in type 2 diabetes patients. This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes ...
Qichun Zhang +8 more
doaj +1 more source
Immunostainings of CAR-3T3-L1 adipocytes overexpressing Oip5.
, 2014 A, Images of EdU staining in the adenovirus-transfected Coxsackie-Adenovirus Receptor (CAR)-3T3-L1 adipocytes. CAR-3T3-L1 adipocytes were stained with 5-ethynyl-2′-deoxyuridine (EdU) and 4′,6-diamidino-2-phenylindole (DAPI) and analyzed by HS All-in-one ...
Yu Tsushima (465409) +11 more
core +1 more source
JSFA reports, EarlyView.Abstract The dietary and lifestyle practices have predominantly compromised human health, which are influenced by modernization and industrialization. Hypercholesterolemia, caused by the consumption of fatty and fried foods and a sedentary lifestyle, is a major modifiable risk factor for cardiovascular disease and commonly coexists with obesity ...
Muhammad Usman Khalid +8 more
wiley +1 more source