Results 71 to 80 of about 235,191 (202)

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activitys⃞

Journal of Lipid Research, 2008
In the course of an effort to identify the regulators for peroxisome proliferator-activated receptor γ (PPARγ)-dependent perilipin gene expression, we found that tribbles homolog 3 (TRB3), containing a single kinase domain without enzymatic activity ...
Yu Takahashi, Nobumichi Ohoka, Hidetoshi Hayashi, Ryuichiro Sato   +3 more
doaj   +1 more source

Dietary Flavonoid Hyperoside Ameliorates High‐Fat Diet‐Induced Type 2 Diabetes Mellitus by Enhancing Brown Adipose Tissue Thermogenesis, White Adipose Tissue Browning, and Gut Microbiota Remodeling

Phytotherapy Research, EarlyView.
Hyperoside ameliorates metabolic dysfunction in high‐fat diet‐induced type 2 diabetic mice, accompanied by enhanced brown adipose tissue thermogenic activity, inguinal white adipose tissue browning‐related changes, reduced M1 macrophage polarization, and gut microbiota remodeling.
WeiFeng Cai, WenXin Zeng, Yu Luo, Qiang Liu, CuiPing Jiang, YanKui Yi, JieYu Chen, ChunYan Shen   +7 more
wiley   +1 more source

Efectos de la modulación de los receptores PPAR? y de Glucocorticoides en la expresión de Caveolina-1 en células 3T3-L1 [PDF]

, 2011
Caveolina-1es una proteína con un importante papel en el tejido adiposo, donde participa en la respuesta a insulina y el metabolismo de lípidos. La expresión de Caveolina-1 aumenta durante la adipogénesis de células 3T3-L1, pero se desconocen los ...
Domínguez Moré, Gina Paola
core  

Genome-wide profiling of Prmt5 binding during 3T3-L1 adipogenesis

, 2023
This  study aims to determine the unique role of Prmt5 during  adipogenesis by profiling Prmt5’s chromatin binding sites genome-wide at  three time points during 3T3-L1 differentiation.
Sabriya Syed (14525993)
core   +1 more source

Cinnamic Acid Attenuates Ethanol‐Exacerbated Hepatocyte Pyroptosis in Type 2 Diabetes via AMPK‐Mediated NLRP3/GSDMD Inhibition

Phytotherapy Research, EarlyView.
CA directly binds to and activates AMPK to suppress NLRP3/GSDMD signaling, thereby alleviating hepatocyte pyroptosis in T2DM mice. ABSTRACT Type 2 diabetes mellitus (T2DM) is frequently accompanied by chronic ethanol (ET) consumption, which worsens metabolic dysregulation and organ damage.
Huaiying Tang, Qin Xiang, Yue Zhang, Yu Zhang, Xiangxiang Fu, Liming Tan, Yongli Zhang, Siqi Li, Dong Gong, Xu Guo, Yonghong Zhang, Li Chen, Tao Zheng, Qibin Wang   +13 more
wiley   +1 more source

Downregulation of REDD1 expression inhibits lipogenesis in 3T3-L1 adipocytes.

, 2012
3T3-L1 adipocytes were transfected with REDD1 siRNA. 48 h after transfection, 3T3-L1 adipocytes were incubated with [3H] sodium acetate (0.4 mmol/l, 0.5 µCi/ml) in absence or in presence of insulin 1 nM for 1 hour at 37°C.
Claire Regazzetti (111898), Pascal Peraldi (70204), Sophie Giorgetti-Peraldi (111912), Yannick Le Marchand-Brustel (111906), Jean-François Tanti (111910), Karine Dumas (111902)   +5 more
core   +1 more source

Magnoflorine Ameliorates MASH in Mice Fed a High‐Fat and High‐Fructose Diet by Promoting AMPK‐Mediated Lipophagy and Fatty Acid Oxidation

Phytotherapy Research, EarlyView.
Magnoflorine ameliorates metabolic dysfunction‐associated steatohepatitis by promoting AMPKα‐mediated lipophagy and fatty acid oxidation. ABSTRACT Emerging as a significant clinical burden, metabolic dysfunction‐associated steatohepatitis (MASH) continues to challenge global healthcare systems due to limited effective interventions.
Zhengjie Lu, Tongyun Mao, Longxin Chai, Kaiqi Chen, Kexin Liu, Cong Zhang, Hao Kou   +6 more
wiley   +1 more source