Results 81 to 90 of about 58,354 (259)

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

The effects of Ganoderma lucidum herba pharmacopuncture on 3T3-L1 preadipocyte differentiation

Journal of Pharmacopuncture, 2008
Objective : The purpose of this study is to investigate the effects of Ganoderma lucidum herba pharmacopuncture (GHP) on the adipogenesis in 3T3-L1 preadipocytes. Methods : 3T3- L1 preadipocytes were differentiated with adipogenic reagents by incubating
Chea-woo Lee, Hyun-Min Yoon, Kyung-Hwa Kang   +2 more
doaj   +1 more source

High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells. [PDF]

PLoS ONE, 2011
BACKGROUND: High density lipoprotein (HDL) was reported to decrease plasma glucose and promote insulin secretion in type 2 diabetes patients. This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes ...
Qichun Zhang, Yun Zhang, Haihua Feng, Rui Guo, Lai Jin, Rong Wan, Lina Wang, Cheng Chen, Shengnan Li   +8 more
doaj   +1 more source

Angiotensin II Inhibits Adipogenic Differentiation and Promotes Mature Adipocyte Browning through the Corepressor CtBP1

Biomedicines, 2022
The mechanisms of angiotensin II (Ang II) on regulating adipogenic differentiation and function remain unknown. In this study, we focus on revealing the role of C-terminal-binding protein 1 (CtBP1) on Ang II-mediated adipogenic differentiation and mature
Xiuying Liang, Jingwen Sun, Haijing Guan, Qingyu Zhu, Wenjuan Yao   +4 more
doaj   +1 more source

A 3-D in vitro co-culture model of mammary gland involution. [PDF]

, 2014
Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru, Cameron, Ruth E., Campbell, Jonathan J., Davidenko, Natalia, Sargeant, Timothy J., Watson, Christine J.   +5 more
core   +3 more sources

Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes [PDF]

Cell Research, 2008
cAMP and protein kinase A (PKA) are widely known as signaling molecules that are important for the induction of adipogenesis. Here we show that a strong increase in the amount of cAMP inhibits the adipogenesis of 3T3-L1 fibroblast cells. Stimulation of PKA activity suppresses adipogenesis and, in contrast, inhibition of PKA activity markedly ...
Fuqiang, Li, Dongmei, Wang, Yiran, Zhou, Bo, Zhou, Yanan, Yang, Hehua, Chen, Jianguo, Song   +6 more
openaire   +2 more sources

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

TC10 Is Regulated by Caveolin in 3T3-L1 Adipocytes

PLoS ONE, 2012
TC10 is a small GTPase found in lipid raft microdomains of adipocytes. The protein undergoes activation in response to insulin, and plays a key role in the regulation of glucose uptake by the hormone.TC10 requires high concentrations of magnesium in order to stabilize guanine nucleotide binding.
Dave Bridges, Louise Chang, Irfan J Lodhi, Natalie A Clark, Alan R Saltiel   +4 more
openaire   +4 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

TG-interacting factor is required for the differentiation of preadipocytes

Journal of Lipid Research, 2008
The accumulation of visceral adipose tissue is closely associated with insulin resistance and metabolic syndrome. Therefore, it is important to identify genes that are required for adipocyte differentiation.
Takahiro Horie, Koh Ono, Minako Kinoshita, Hitoo Nishi, Kazuya Nagao, Teruhisa Kawamura, Yukiko Abe, Hiromichi Wada, Akira Shimatsu, Toru Kita, Koji Hasegawa   +10 more
doaj   +1 more source