Results 21 to 30 of about 946,668 (293)
PLoS ONE, 2022 Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim +4 more
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Inhibition of adipocyte differentiation by RORα [PDF]
FEBS Letters, 2009 Here we show that gene expression of the nuclear receptor RORα is induced during adipogenesis, with RORα4 being the most abundantly expressed isoform in human and murine adipose tissue. Over‐expression of RORα4 in 3T3‐L1 cells impairs adipogenesis as shown by the decreased expression of adipogenic markers and lipid accumulation, accompanied by ...
Duez, Hélène +7 more
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Role of calpain in adipocyte differentiation [PDF]
Proceedings of the National Academy of Sciences, 1999 Evidence is presented that the calcium-activated protease, calpain, is required for differentiation of 3T3-L1 preadipocytes into adipocytes induced by methylisobutylxanthine (a cAMP phosphodiesterase inhibitor), dexamethasone, and insulin.
Y M, Patel, M D, Lane
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Molecular Mechanism of Stem Cell Differentiation into Adipocytes and Adipocyte Differentiation of Malignant Tumor [PDF]
Stem Cells International, 2020 Adipogenesis is the process through which preadipocytes differentiate into adipocytes. During this process, the preadipocytes cease to proliferate, begin to accumulate lipid droplets, and develop morphologic and biochemical characteristics of mature adipocytes. Mesenchymal stem cells (MSCs) are a type of adult stem cells known for their high plasticity
Kexin Zhang +7 more
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Actin depolymerization enhances adipogenic differentiation in human stromal stem cells
Stem Cell Research, 2018 Human stromal stem cells (hMSCs) differentiate into adipocytes that play a role in skeletal tissue homeostasis and whole body energy metabolism. During adipocyte differentiation, hMSCs exhibit significant changes in cell morphology suggesting changes in ...
Li Chen +4 more
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Improved Protocol to Study Osteoblast and Adipocyte Differentiation Balance [PDF]
, 2022 Adipogenesis-osteoblastogenesis balance-rupture is relevant in multiple diseases. Current human mesenchymal stem cells (hMSCs) in vitro differentiation models are expensive, and are hardly reproducible.
María Guillán-Fresco +17 more
core +1 more source
Nature Communications, 2017 Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to ...
Ji-Eun Lee +9 more
doaj +1 more source
Insulin-stimulated lipid accumulation is inhibited by ROS-scavenging chemicals, but not by the Drp1 inhibitor Mdivi-1. [PDF]
PLoS ONE, 2017 Adipocyte differentiation is regulated by intracellular reactive oxygen species (ROS) generation and mitochondrial fission and fusion processes. However, the correlation between intracellular ROS generation and mitochondrial remodeling during adipocyte ...
Jung-Hak Kim +5 more
doaj +1 more source
Blockade of adipocyte differentiation by cordycepin [PDF]
British Journal of Pharmacology, 2012 BACKGROUND AND PURPOSE Cordyceps militaris has the potential to suppress differentiation of pre‐adipocytes. However, the active entities in the extract and the underlying mechanisms of its action are not known. Hence, we investigated whether and how cordycepin (3′‐deoxyadenosine), a constituent of C.
Shuhei, Takahashi +6 more
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The role of Akt in adipocyte differentiation.
, 2009 The role of Akt in adipocyte ...
Deepa. Sundararajan (7965644)
core +3 more sources