Results 101 to 110 of about 171,663 (318)

Adiposity and cancer risk: new mechanistic insights from epidemiology [PDF]

, 2015
Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for many common adult cancers. Over the past decade, epidemiological data have shown that adiposity-cancer risk associations are specific for gender, site, geographical ...
Matthias Egger, Egger, Matthias, Marcel Zwahlen, Zwahlen, Marcel, Andrew G. Renehan, Renehan, Andrew G   +5 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Percent of body fat, fat-mass, fat-free mass and assessment of body composition among rural school-going children of Eastern-India

Anthropological Review, 2018
Percent of body fat (PBF), fat mass (FM) and fat free mass (FFM) are useful indicators for the assessment of body composition. The present study was conducted among 1351 children (boys: 660; girls: 691) aged 5-12 years residing in West Bengal, Eastern ...
Debnath Sampriti, Mondal Nitish, Sen Jaydip   +2 more
doaj   +1 more source

Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors.

, 2005
BACKGROUND: Atherosclerosis develops from childhood, but the determinants of this preclinical stage remain uncertain. We examined the relations of classic coronary risk factors, adiposity and its associated metabolic disturbances, to arterial ...
Donald, AE, Oliver, C, Whincup, PH, Gilg, JA, Katterhorn, M, Cook, DG, Deanfield, JE   +6 more
core  

Physical activity, obesity and cardiometabolic risk factors in 9-to 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE) [PDF]

, 2010
Physical inactivity is implicated in unfavourable patterns of obesity and cardiometabolic risk in childhood. However, few studies have quantified these associations using objective physical activity measurements in children from different ethnic groups ...
A. R. Rudnicka, Rudnicka, A. R., Owen, C.G., Ekelund, U, Whincup, PH, Rudnicka, AR, Sattar, N, Sattar, N., U. Ekelund, Nightingale, C.M., P. H. Whincup, Nightingale, CM, Ekelund, U., Owen, CG, C. G. Owen, N. Sattar, Whincup, P. H., C. M. Nightingale, Cook, DG, D. G. Cook, Cook, D. G.   +20 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Cellularity of porcine adipose tissue: effects of growth and adiposity

Journal of Lipid Research, 1977
Adipose tissue, from two depots in pigs of three breeding groups with different propensities to fatten, was characterized in terms of weight of the adipose tissue organ, adipose cell number, and mean cell volume as determined by electronic counting of adipose cells fixed with osmium tetroxide.
R L Hood, C E Allen
openaire   +3 more sources

Insulin resistance and its relation to adiposity, cardiorespiratory fitness and dietary intake among Azorean adolescents [PDF]

, 2012
Insulin resistance is an important compo nent in the development of metabolic syndrome and lifestyle-related diseases. The aim of the present study is to investigate the relationship between insulin resistance (IR), adiposity, cardiorespiratory fitness ...
Soares-Miranda, L., Vale, S., Marques, A. I., Santos, P. C., Moreira, C., Abreu, S., Rute, Santos, Mota, J.   +7 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source