Results 101 to 110 of about 264,725 (308)

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants [PDF]

, 2017
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index ...
Anderson, Jana, Bailey, Mark E.S., Celis-Morales, Carlos, Gill, Jason M.R., Gray, Stuart, Guo, Yibing, Iliodromiti, Stamatina, Lyall, Donald M., Mackay, Daniel F., Pell, Jill, Petermann, Fanny, Sattar, Naveed, Steell, Lewis, Welsh, Paul   +13 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Breastfeeding shows a protective trend toward adolescents with higher abdominal adiposity [PDF]

, 2014
Objective: The question of whether breastfeeding has a protective effect against the development of overweight or obesity later in life remains controversial, especially during adolescence.
De Henauw, Stefaan, Dietrich, Sabine, Duhamel, Alain, Garcia Artero, Enrique, Gottrand, Frédéric, Manios, Yannis, Molnar, Denes, Moreno, Luis Aznar, Piccinelli, Raffaela, Rousseaux, Julien, Salleron, Julia, Sjöström, Michael, Turck, Dominique   +12 more
core   +3 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Heart Rate Is a Better Predictor of Cardiorespiratory Fitness Than Heart Rate Variability in Overweight/Obese Children: The ActiveBrains Project

Frontiers in Physiology, 2019
Cardiac autonomic function can be quantified through mean heart rate (HR) or heart rate variability (HRV). Numerous studies have supported the utility of different HRV parameters as indicators of cardiorespiratory fitness (CRF).
Abel Plaza-Florido, Jairo H. Migueles, Jose Mora-Gonzalez, Pablo Molina-Garcia, Pablo Molina-Garcia, Maria Rodriguez-Ayllon, Cristina Cadenas-Sanchez, Irene Esteban-Cornejo, Irene Esteban-Cornejo, Patricio Solis-Urra, Patricio Solis-Urra, Carlos de Teresa, Ángel Gutiérrez, Nathalie Michels, Jerzy Sacha, Jerzy Sacha, Francisco B. Ortega, Francisco B. Ortega   +17 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Lower cardiorespiratory fitness contributes to increased insulin resistance and fasting glycaemia in middle-aged South Asian compared with European men living in the UK [PDF]

, 2013
AIMS/HYPOTHESIS: This study aimed to determine the extent to which increased insulin resistance and fasting glycaemia in South Asian men, compared with white European men, living in the UK, was due to lower cardiorespiratory fitness (maximal oxygen ...
A Misra, A Misra, A. McConnachie, AA Atienza, AM Fehily, B Mukhopadhyay, C Bouchard, C Bouchard, C Rheaume, CA Celis-Morales, CM Fischbacher, CP Hardy, D. Purves, DR Matthews, ED Williams, ED Williams, ET Howley, F Razak, GJG Davey, HL Taylor, J. M. R. Gill, J. Wilson, JM Gill, JM Gill, LJ Gray, LM Hall, M Chandalia, M Hagstromer, M Marfell-Jones, M Wei, MA Assaad El, MN Poppel van, N. Ghouri, N. Sattar, NG Forouhi, NG Forouhi, O Dewit, PM McKeigue, PS Freedson, RJ Shephard, RP Troiano, S Kumar, T Yates, TA Schmitt, TG Ceaser, The Interact Consortium, U Wisloff, WH Herman   +47 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source