Results 81 to 90 of about 190,728 (311)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Adiposity induced by adenovirus 5 inoculation

, 2005
OBJECTIVE: To investigate the effect of viral inoculation by adenovirus 5 (Ad5) on body composition in a mouse model. DESIGN: Longitudinal monitoring before and after a single injection of virus or saline. SUBJECTS: Two groups of CD1 mice, one group
So, P.W., Bell, J.D., Herlihy, A.H.
core   +1 more source

A better performing algorithm for identification of implausible growth data from longitudinal pediatric medical records

Scientific Reports
Tracking trajectories of body size in children provides insight into chronic disease risk. One measure of pediatric body size is body mass index (BMI), a function of height and weight. Errors in measuring height or weight may lead to incorrect assessment
Kylie K. Harrall, Sarah M. Bird, Keith E. Muller, Lauren A. Vanderlinden, Maya E. Payton, Anna Bellatorre, Dana Dabelea, Deborah H. Glueck   +7 more
doaj   +1 more source

Adipose tissue macrophages: their role in adipose tissue remodeling [PDF]

Journal of Leukocyte Biology, 2010
Abstract This review summarizes the role of macrophages in adipose tissue remodeling, particularly focusing on the paracrine loop between adipocytes and macrophages. The adipose tissue secretes a large number of bioactive substances, adipocytokines, which may be involved in a variety of physiologic and pathologic processes.
Takayoshi, Suganami, Yoshihiro, Ogawa
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Preventing Chronic Disease (PCD) [PDF]

IntroductionWe assessed the independent effects of socioeconomic status, sex, adiposity, and physical activity on C-reactive protein in young adults.MethodsDuring the fall semester of their first year, college students (n = 177; mean age, 18.1 y; 66.7 ...

core   +1 more source

Placental insulin-mTOR and stress–inflammatory signaling patterns are associated with childhood adiposity

BMC Medicine
Background Placental signaling pathways regulate nutrient transport and fetal growth, with potential long-term consequences for offspring metabolic health.
Ellen C. Francis, Kristen E. Boyle, Lauren E. Gyllenhammer, Dana Dabelea, Thomas Jansson, Wei Perng   +5 more
doaj   +1 more source

Integrative Genomic Analysis Predicts Regulatory Role of N6-Methyladenosine-Associated SNPs for Adiposity

Frontiers in Cell and Developmental Biology, 2020
Genome-wide association studies have identified many susceptible loci to explore the genetic factors of adiposity. However, the specific mechanisms by which these SNPs (single nucleotide polymorphism), particularly in the non-coding region, are involved ...
Weimin Lin, Hao Xu, Quan Yuan, Quan Yuan, Shiwen Zhang, Shiwen Zhang   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source