Results 81 to 90 of about 171,663 (318)

Preventing Chronic Disease (PCD) [PDF]

IntroductionWe assessed the independent effects of socioeconomic status, sex, adiposity, and physical activity on C-reactive protein in young adults.MethodsDuring the fall semester of their first year, college students (n = 177; mean age, 18.1 y; 66.7 ...

core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction [PDF]

International Journal of Endocrinology, 2014
The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome.
Marco Calogero Amato, Carla Giordano
openaire   +4 more sources

Preprint: Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease

, 2021
To understand the consequences of higher adiposity uncoupled from its adverse metabolic effects, we selected 37 diseases associated with obesity and genetic variants associated with different aspects of excess weight including metabolically “favourable ...
Lam Tsoi, Christopher Kabrhel, Philip E Stuart, Marc Gunter, Emma Vincent, Robin Beaumont, Philip Law, Caroline Bull, Hanieh Yaghootkar, Elizabeth Thomas, Timothy Frayling, Nikos Papadimitriou, Joshua Bell, Naveed Sattar, Jessica Tyrrell, Andrew Wood, Richard Houlston, Susan Martin, Jimmy Bell, Matthew Bown, James Elder   +20 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Integrative Genomic Analysis Predicts Regulatory Role of N6-Methyladenosine-Associated SNPs for Adiposity

Frontiers in Cell and Developmental Biology, 2020
Genome-wide association studies have identified many susceptible loci to explore the genetic factors of adiposity. However, the specific mechanisms by which these SNPs (single nucleotide polymorphism), particularly in the non-coding region, are involved ...
Weimin Lin, Hao Xu, Quan Yuan, Quan Yuan, Shiwen Zhang, Shiwen Zhang   +5 more
doaj   +1 more source

Adipose tissue macrophages: their role in adipose tissue remodeling [PDF]

Journal of Leukocyte Biology, 2010
Abstract This review summarizes the role of macrophages in adipose tissue remodeling, particularly focusing on the paracrine loop between adipocytes and macrophages. The adipose tissue secretes a large number of bioactive substances, adipocytokines, which may be involved in a variety of physiologic and pathologic processes.
Takayoshi, Suganami, Yoshihiro, Ogawa
openaire   +2 more sources

Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15 [PDF]

, 2010
Background: Little is known about whether associations between childhood adiposity and later adverse cardiovascular health outcomes are driven by tracking of overweight from childhood to adulthood and/or by vascular and metabolic changes from childhood ...
Kate Tilling, Smith George Davey, Benfield, LL, Lawlor Debbie A., Sattar, N, Sattar, N., Smith, GD, Ness, AR, Andy R. Ness, Tilling, K., Sattar Naveed, Laura D Howe, Benfield Li, Davey Smith, G, Debbie A. Lawlor, Tilling Kate, Logue Jennifer, Jennifer Logue, Howe Laura D., Howe, L.D., Andy R Ness, Lawlor, D, Li Benfield, Logue, J., Logue, J, Benfield, L., Ness Andy R., Naveed Sattar, Lawlor, DA, Debbie A Lawlor, Laura D. Howe, Hernandez, A.V., George Davey Smith, Davey Smith, G., Howe, LD, Ness, A.R., Benfield, L, Lawlor, D.A., Tilling, K, Ness, A   +39 more
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Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source