Results 61 to 70 of about 264,725 (308)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cardiac Concomitants of Feedback and Prediction Error Processing in Reinforcement Learning

Frontiers in Neuroscience, 2017
Successful learning hinges on the evaluation of positive and negative feedback. We assessed differential learning from reward and punishment in a monetary reinforcement learning paradigm, together with cardiac concomitants of positive and negative ...
Lucas Kastner, Lucas Kastner, Jana Kube, Jana Kube, Jana Kube, Arno Villringer, Arno Villringer, Arno Villringer, Arno Villringer, Jane Neumann, Jane Neumann, Jane Neumann   +11 more
doaj   +1 more source

Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Journal of Veterinary Internal Medicine, 2021
Background Blood l‐lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l‐lactate concentrations are positively correlated with measures of insulin ...
Bettina Dunkel, Edward J. Knowles, Yu‐Mei Chang, Nicola J. Menzies‐Gow   +3 more
doaj   +1 more source

Inflammation mediates the effect of adiposity and lipid metabolism indicators on the embryogenesis of PCOS women undergoing in vitro fertilization/intracytoplasmic sperm injection

Frontiers in Endocrinology, 2023
BackgroundPolycystic ovary syndrome (PCOS) is a complex reproductive endocrine and metabolic disease affecting women of reproductive age. The low-grade chronic inflammation in PCOS is considered to be associated with obesity and dyslipidemia.
Huahua Jiang, Huahua Jiang, Huahua Jiang, Huahua Jiang, Lixue Chen, Lixue Chen, Lixue Chen, Lixue Chen, Tian Tian, Tian Tian, Tian Tian, Tian Tian, Huifeng Shi, Huifeng Shi, Huifeng Shi, Ning Huang, Ning Huang, Ning Huang, Ning Huang, Hongbin Chi, Hongbin Chi, Hongbin Chi, Hongbin Chi, Rui Yang, Rui Yang, Rui Yang, Rui Yang, Xiaoyu Long, Xiaoyu Long, Xiaoyu Long, Xiaoyu Long, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao   +36 more
doaj   +1 more source

Dietary determinants of changes in waist circumference adjusted for body mass index - a proxy measure of visceral adiposity [PDF]

, 2010
Background Given the recognized health effects of visceral fat, the understanding of how diet can modulate changes in the phenotype “waist circumference for a given body mass index (WCBMI)”, a proxy measure of visceral adiposity, is deemed necessary ...
A, D.L., van der, Angquist, L., Boeing, H., Feskens, E.J.M., Forouhi, N.G., Halkjaer, J., Huaidong, D.U., Jakobsen, M.U., Masala, G., Overvad, K., Palli, D., Riboli, E., Romaguera, D., Sorensen, T., Steffen, A., Tjonneland, A., Wareham, N.   +16 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset

Scientific Reports
Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity.
Catherine Kim, Kylie K. Harrall, Deborah H. Glueck, Christine Hockett, Dana Dabelea   +4 more
doaj   +1 more source

(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distributionResearch in context

EBioMedicine, 2019
Background: In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying ...
Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Torunn Rønningen, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Annette Horstmann, Arno Villringer, Matthias Blüher, Yvonne Böttcher   +10 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Efficacy of DiaLife, an education program for relatives of adult patients with diabetes – study protocol of a cluster randomized controlled trial

Trials, 2019
Background The global prevalence of diabetes mellitus (DM) has been increasing over recent decades. In Germany, the prevalence for DM type 1 and type 2 in adults is estimated at about 7.7%.
M. Bernard, N. Müller, L. Hecht, G. Fabisch, A. Harder, C. Luck-Sikorski   +5 more
doaj   +1 more source