Results 61 to 70 of about 171,663 (318)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Vitamin D deficiency is associated with cardiovascular events among adults, but it is unclear whether early‐life vitamin D deficiency influences cardiovascular risk factors in children. Methods and Results We measured total and bioavailable 25‐
Katherine A. Sauder, Alexandra V. Stamatoiu, Elina Leshchinskaya, Brandy M. Ringham, Deborah H. Glueck, Dana Dabelea   +5 more
doaj   +1 more source

Next Generation Bone Marrow Adiposity Researchers: Report From the 1st BMAS Summer School 2021

, 2022
The first International Summer School on Bone Marrow Adiposity was organized by members of Bone Marrow Adiposity Society and held virtually on September 6-8 2021.
Labella, R., Vlug, Annegreet, Labella, Rossella, Vlug, A., Avilkina, V., Little-Letsinger, Sarah, Tencerova, Michaela, Avilkina, Viktorija, Little-Letsinger, S., Sarkis, R., Palmisano, Biagio, Palmisano, B., Tencerova, M., Sarkis, Rita   +13 more
core   +1 more source

Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease [PDF]

, 2021
To understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants, one with ‘adverse’ metabolic effects (UFA) and the other with, paradoxically ...
Yaghootkar, H., Wood, A.R., Cule, M, Thomas, E.L., Martin, S., Liu, Y., Bell, J.D., Sorokin, E., Frayling, T., Whitcher, B., Beaumont, R.N., Basty, N., Tyrrell, J.   +12 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis

Cancer Medicine, 2023
Background The associations of adiposity with aggressive prostate cancer risk are unclear. Using two‐sample Mendelian randomization, we assessed the association of metabolically unfavourable adiposity (UFA), favourable adiposity (FA) and for comparison ...
Aurora Perez‐Cornago, Karl Smith‐Byrne, Emma Hazelwood, Cody Z. Watling, Susan Martin, Timothy Frayling, Sarah Lewis, Richard M. Martin, Hanieh Yaghootkar, Ruth C. Travis, Timothy J. Key   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome

Frontiers in Nutrition, 2021
Numerous endogenous functions related to antioxidant processes, reproduction, and thyroid metabolism, as well as actions related to glycemic control, have been attributed to selenium.
Acsa de Castro Santos, Anna Flavia Ferreira Passos, Luciana Carla Holzbach, Luciana Carla Holzbach, Cristiane Cominetti   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A better performing algorithm for identification of implausible growth data from longitudinal pediatric medical records

Scientific Reports
Tracking trajectories of body size in children provides insight into chronic disease risk. One measure of pediatric body size is body mass index (BMI), a function of height and weight. Errors in measuring height or weight may lead to incorrect assessment
Kylie K. Harrall, Sarah M. Bird, Keith E. Muller, Lauren A. Vanderlinden, Maya E. Payton, Anna Bellatorre, Dana Dabelea, Deborah H. Glueck   +7 more
doaj   +1 more source