Results 61 to 70 of about 190,728 (311)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development [PDF]

, 2011
An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ...
McCarthy, Mark I, Palmer, Colin N.A., Anneli Pouta, Yoav Ben-Shlomo, Warrington, N., Ann-Christine Syvänen, Cole, Tim, Mook-Kanamori, D.O. (Dennis), Lawrence Robert, Palmer, C., Vincent W V Jaddoe, Kaakinen, M, Palmer Lyle J., Palmer, Colin N. A., null null, Millwood, Iona Y., Laurent Briollais, Kaakinen, Marika, Tim J Cole, Johanna K Sandling, Palmer, Lyle, Palmer, CN, Davey Smith George, Craig E Pennell, Mook-Kanamori Dennis O., Briollais, L, Lawrence, R., Davey Smith, George, Palmer, Colin NA, Bennett, Amanda J, Palmer, Lyle J., Johanna K. Sandling, Timpson, Nicholas J, Nicole M. Warrington, Vincent W. V. Jaddoe, Sovio, U, Marika Kaakinen, Cole, Tim J, Palmer, C.N.A. (Colin), Jaddoe, Vincent W. V., Briollais, L., Amanda J. Bennett, Iona Y Millwood, Early Growth Genetics Consortium, Lawrence, R, Joanne Cecil, Cecil, J, Pouta, Anneli, Sandling, Johanna K., Smith, GD, Sovio, U. (Ulla), Lawrence, R.W. (Robert), Millwood, IY, Syvänen, Ann-Christine, Warrington, Nicole M., Timpson, Nicholas, Lawrie J. Beilin, Smith, G., Jaddoe, V., Cecil Joanne, Beilin, Lawrie J., Jarvelin, M-R, Craig E. Pennell, Laitinen Jaana, Nicole M Warrington, Mook-Kanamori, DO, Cole, T.J. (Tim), Mook-Kanamori, Dennis O., Järvelin Marjo-Riitta, et al., Pouta, A., Beilin, Lawrie J, McCarthy, MI, Lyle J Palmer, McCarthy Mark I., Pennell, Craig E., Mook-Kanamori, D., Warrington, N.M. (Nicole), Mark I. McCarthy, Davey Smith, G, Palmer Colin N. A., Cole, TJ, Warrington, Nicole M, Briollais Laurent, Molitor John, Jaddoe Vincent W. V., Pennell, C.E. (Craig), Briollais, Laurent, Dennis O. Mook-Kanamori, McCarthy, Mark I., John Molitor, for the EGG, Consortium, Palmer C N, A, Briollais, L. (Laurent), George Davey Smith, Jaddoe, VW, Jaddoe, VWV, Warrington Nicole M., Timpson, NJ, Molitor, J. (John), Nicholas J Timpson, Pennell, CE, Nicholas J. Timpson, Pennell, Craig E, Bennett, A.J. (Amanda), Dennis O Mook-Kanamori, Laitneen, J., Pouta, A, Sandling, JK, Molitor, J., Järvelin, Marjo-Riitta, Syvänen Ann-Christine, Cecil, Joanne Elizabeth, Millwood, Iona, Cole, Tim J., Smith, George Davey, McCarthy, Mark, Laitinen, J, Colin N. A. Palmer, Colin N A Palmer, Ben-Shlomo, Yoav, Jaana Laitinen, Kaakinen Marika, Sovio, U., Palmer, Lyle J, Robert Lawrence, Pennell Craig E., Kaakinen, M., Lawrence, Robert, Bennett, Amanda, Amanda J Bennett, Palmer, L., Jaddoe, Vincent WV, Sandling, J.K. (Johanna), Iona Y. Millwood, Beilin, Lawrie, Syvänen, Ann-Christine,, Mook-Kanamori, Dennis O, Pouta Anneli, Syvänen, A.-C., Bennett Amanda J., Sandling, J., Jaddoe, V.W.V. (Vincent), Sandling, Johanna K, Sovio Ulla, Beilin, LJ, Cecil, J., Bennett, Amanda J., Molitor, J, Palmer, LJ, Ben-Shlomo, Y., Lyle J. Palmer, Jaddoe, Vincent, Millwood, I., Beilin, L., Syvanen, A-C, Timpson Nicholas J., Jarvelin, MR, Bennett A, J, Järvelin, M.R., Sandling, Johanna, Lawrie J Beilin, Ben-Shlomo, Y, Beilin, L.J. (Lawrence), Syvanen, Ann-Christin, Bennett, AJ, Millwood, Iona Y, Laitinen, Jaana, Ulla Sovio, Bennett, A., Sovio, Ulla, Laitinen, J. (Jaana), Tim J. Cole, Millwood Iona Y., Timpson, Nicholas J., Smith, A.V. (Davey), Palmer, CNA, Cole Tim J., Mark I McCarthy, Mook, Dennis, McCarthy M, I, Cecil, Joanne, Pouta, A. (Anneli), Timpson, N.J. (Nicholas), Millwood, I.Y. (Iona), Beilin Lawrie J., Syvanen, A., Molitor, John, Pennell, Craig, Sandling Johanna K., Cecil, J. (Joanne), Sandling, Johanna K.,, Kaakinen, M. (Marika), Marjo-Riitta Järvelin, Warrington, NM, Ben-Shlomo Yoav, McCarthy, M.I. (Mark), Syvanen, AC, Palmer, Colin N. A.; id_orcid   +198 more
core   +2 more sources

Adiposity in British secondary school children: a population based study

, 2008
Summary:Adiposity is defined as the property of containing fat. Excessive adiposity is a cause of both morbidity and mortality in adults. Important consequences include increased risks of type 2 diabetes, coronary heart disease and stroke, (particularly ...
Odoki, Katherine Helen
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. [PDF]

, 2005
BACKGROUND: Atherosclerosis develops from childhood, but the determinants of this preclinical stage remain uncertain. We examined the relations of classic coronary risk factors, adiposity and its associated metabolic disturbances, to arterial ...
Donald, AE, Oliver, C, Whincup, PH, Gilg, JA, Katterhorn, M, Cook, DG, Deanfield, JE   +6 more
core  

Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Vitamin D deficiency is associated with cardiovascular events among adults, but it is unclear whether early‐life vitamin D deficiency influences cardiovascular risk factors in children. Methods and Results We measured total and bioavailable 25‐
Katherine A. Sauder, Alexandra V. Stamatoiu, Elina Leshchinskaya, Brandy M. Ringham, Deborah H. Glueck, Dana Dabelea   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Next Generation Bone Marrow Adiposity Researchers: Report From the 1st BMAS Summer School 2021

, 2022
The first International Summer School on Bone Marrow Adiposity was organized by members of Bone Marrow Adiposity Society and held virtually on September 6-8 2021.
Labella, R., Vlug, Annegreet, Labella, Rossella, Vlug, A., Avilkina, V., Little-Letsinger, Sarah, Tencerova, Michaela, Avilkina, Viktorija, Little-Letsinger, S., Sarkis, R., Palmisano, Biagio, Palmisano, B., Tencerova, M., Sarkis, Rita   +13 more
core   +1 more source

Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis

Cancer Medicine, 2023
Background The associations of adiposity with aggressive prostate cancer risk are unclear. Using two‐sample Mendelian randomization, we assessed the association of metabolically unfavourable adiposity (UFA), favourable adiposity (FA) and for comparison ...
Aurora Perez‐Cornago, Karl Smith‐Byrne, Emma Hazelwood, Cody Z. Watling, Susan Martin, Timothy Frayling, Sarah Lewis, Richard M. Martin, Hanieh Yaghootkar, Ruth C. Travis, Timothy J. Key   +10 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source