Results 51 to 60 of about 190,728 (311)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

1ST BONE MARROW ADIPOSITY SOCIETY (BMAS) SUMMER SCHOOL

, 2021
The bone marrow in adults consists mostly of fat. There is a direct relationship between bone marrow fat and the occurrence of bone fractures or osteoporosis.
Annegreet Veldhuis, Rita Sarkis, Sarah Little, Michaela Tencerova, Viktorija Avilkina, Biagio Palmisano, Rossella Labella   +6 more
core   +1 more source

Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset

Scientific Reports
Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity.
Catherine Kim, Kylie K. Harrall, Deborah H. Glueck, Christine Hockett, Dana Dabelea   +4 more
doaj   +1 more source

Cardiac Concomitants of Feedback and Prediction Error Processing in Reinforcement Learning

Frontiers in Neuroscience, 2017
Successful learning hinges on the evaluation of positive and negative feedback. We assessed differential learning from reward and punishment in a monetary reinforcement learning paradigm, together with cardiac concomitants of positive and negative ...
Lucas Kastner, Lucas Kastner, Jana Kube, Jana Kube, Jana Kube, Arno Villringer, Arno Villringer, Arno Villringer, Arno Villringer, Jane Neumann, Jane Neumann, Jane Neumann   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Altered adiposity after extremely preterm birth

, 2005
The quantity and distribution of adipose tissue are markers of morbidity risk. The third trimester of human development is a period of rapid adipose tissue deposition. Preterm infants may be at risk of altered adiposity.
Doré, C.J., Hamilton, G., Neena Modi, Uthaya, S.N., Modi, N., Thomas, E.L., Caroline J Doré, Jimmy Bell, Gavin Hamilton, Bell, J.D., Sabita Uthaya, E Louise Thomas   +11 more
core   +1 more source

(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distributionResearch in context

EBioMedicine, 2019
Background: In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying ...
Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Torunn Rønningen, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Annette Horstmann, Arno Villringer, Matthias Blüher, Yvonne Böttcher   +10 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Issues in Modelling Growth Data Within A Life Course Framework [PDF]

This thesis explores, develops and implements modelling strategies for studying relationships between childhood growth and later health, focusing primarily on the relationship between the development of body mass index (BMI) in childhood and later ...
Silverwood, Richard Jonathan
core   +1 more source

Efficacy of DiaLife, an education program for relatives of adult patients with diabetes – study protocol of a cluster randomized controlled trial

Trials, 2019
Background The global prevalence of diabetes mellitus (DM) has been increasing over recent decades. In Germany, the prevalence for DM type 1 and type 2 in adults is estimated at about 7.7%.
M. Bernard, N. Müller, L. Hecht, G. Fabisch, A. Harder, C. Luck-Sikorski   +5 more
doaj   +1 more source