Results 51 to 60 of about 171,663 (318)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Cardiac Concomitants of Feedback and Prediction Error Processing in Reinforcement Learning

Frontiers in Neuroscience, 2017
Successful learning hinges on the evaluation of positive and negative feedback. We assessed differential learning from reward and punishment in a monetary reinforcement learning paradigm, together with cardiac concomitants of positive and negative ...
Lucas Kastner, Lucas Kastner, Jana Kube, Jana Kube, Jana Kube, Arno Villringer, Arno Villringer, Arno Villringer, Arno Villringer, Jane Neumann, Jane Neumann, Jane Neumann   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset

Scientific Reports
Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity.
Catherine Kim, Kylie K. Harrall, Deborah H. Glueck, Christine Hockett, Dana Dabelea   +4 more
doaj   +1 more source

(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distributionResearch in context

EBioMedicine, 2019
Background: In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying ...
Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Torunn Rønningen, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Annette Horstmann, Arno Villringer, Matthias Blüher, Yvonne Böttcher   +10 more
doaj   +1 more source

Issues in Modelling Growth Data Within A Life Course Framework [PDF]

This thesis explores, develops and implements modelling strategies for studying relationships between childhood growth and later health, focusing primarily on the relationship between the development of body mass index (BMI) in childhood and later ...
Silverwood, Richard Jonathan
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Efficacy of DiaLife, an education program for relatives of adult patients with diabetes – study protocol of a cluster randomized controlled trial

Trials, 2019
Background The global prevalence of diabetes mellitus (DM) has been increasing over recent decades. In Germany, the prevalence for DM type 1 and type 2 in adults is estimated at about 7.7%.
M. Bernard, N. Müller, L. Hecht, G. Fabisch, A. Harder, C. Luck-Sikorski   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The influence of the digital divide on face preferences in El Salvador : People without internet access prefer more feminine men, more masculine women, and women with higher adiposity

, 2014
CB received funding from the Russell Trust to support this researchPrevious studies on face preferences have found that online and laboratory experiments yield similar results with samples from developed countries, where the majority of the population ...
Batres, Carlota, Perrett, David I., Carlota Batres (595377), David I Perrett, Batres Carlota, Perrett David I., Carlota Batres, David I. Perrett (32540)   +7 more
core   +1 more source