Results 91 to 100 of about 190,728 (311)

Obesity-Related Hypertension in Children

Frontiers in Pediatrics, 2017
Obesity and hypertension have both been on the rise in children. Each is associated with increased cardiovascular disease risk and both track into adulthood, increasing the prevalence of heart disease and related morbidity and mortality.
Tammy M. Brady
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15 [PDF]

, 2010
Background: Little is known about whether associations between childhood adiposity and later adverse cardiovascular health outcomes are driven by tracking of overweight from childhood to adulthood and/or by vascular and metabolic changes from childhood ...
Kate Tilling, Smith George Davey, Benfield, LL, Lawlor Debbie A., Sattar, N, Sattar, N., Smith, GD, Ness, AR, Andy R. Ness, Tilling, K., Sattar Naveed, Laura D Howe, Benfield Li, Davey Smith, G, Debbie A. Lawlor, Tilling Kate, Logue Jennifer, Jennifer Logue, Howe Laura D., Howe, L.D., Andy R Ness, Lawlor, D, Li Benfield, Logue, J., Logue, J, Benfield, L., Ness Andy R., Naveed Sattar, Lawlor, DA, Debbie A Lawlor, Laura D. Howe, Hernandez, A.V., George Davey Smith, Davey Smith, G., Howe, LD, Ness, A.R., Benfield, L, Lawlor, D.A., Tilling, K, Ness, A   +39 more
core   +1 more source

Association Between Metabolically Different Adiposity Subtypes and Osteoarthritis: A Mendelian Randomization Study

, 2022
OBJECTIVE: In this Mendelian randomisation (MR) study, we investigate the causal effect of metabolically different adiposity subtypes on osteoarthritis. METHODS: We performed two-sample MR using summary-level data for osteoarthritis (10,083 cases and 40 ...
Tesfahun C. Eshetie, Gizat M. Kassie, Daniel Erku, Kassie, Gizat M, Alemayehu Mekonnen, Mekonnen, Alemayehu, Eshetie, Tesfahun C, Lumsden, Amanda, Erku, Daniel, Elina Hyppönen, Mulugeta, Anwar, Hyppönen, Elina, Anwar Mulugeta, Amanda Lumsden   +13 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Physical activity in preschoolers [PDF]

, 2012
Summary: The health benefits of physical activity are clearly established. Physical activity is also thought to be beneficial for children, although morbidity and mortality are established only later in life.
Bürgi, Flavia
core   +1 more source