Results 71 to 80 of about 122,412 (281)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Distributed stochastic gradient descent for link prediction in signed social networks
EURASIP Journal on Advances in Signal Processing, 2019 This paper considers the link prediction problem defined over a signed social network, where the relationship between any two network users can be either positive (friends) or negative (foes).
Han Zhang, Gang Wu, Qing Ling
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Regression and Singular Value Decomposition in Dynamic Graphs
, 2020 Most of real-world graphs are {\em dynamic}, i.e., they change over time. However, while problems such as regression and Singular Value Decomposition (SVD) have been studied for {\em static} graphs, they have not been investigated for {\em dynamic ...
Chehreghani, Mostafa Haghir
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Reducing the adjacency matrix of a tree [PDF]
The Electronic Journal of Linear Algebra, 1996 Summary: Let \(T\) be a tree, \(A\) its adjacency matrix, and \(\alpha\) be a scalar. We describe a linear-time algorithm for reducing the matrix \(\alpha I_n + A\). Applications include computing the rank of \(A\), finding a maximum matching in \(T\), computing the rank and determinant of the associated neighborhood matrix, and computing the ...
Fricke, Gerd H. +3 more
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Cospectral constructions for several graph matrices using cousin vertices
Special Matrices, 2021 Graphs can be associated with a matrix according to some rule and we can find the spectrum of a graph with respect to that matrix. Two graphs are cospectral if they have the same spectrum.
Lorenzen Kate
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
The adjacency matrix of one type of graph and the Fibonacci numbers [PDF]
, 2012 Recently there is huge interest in graph theory and intensive study on computing integer powers of matrices. In this paper, we investigate relationships between one type of graph and well-known Fibonacci sequence.
Bozkurt, Durmuş +2 more
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