Results 131 to 140 of about 228,749 (323)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

On the morpho-syntactic properties of relational adjectives in romanian and spanish

open access: yesBucharest Working Papers in Linguistics, 2010
This paper analyzes the morpho-syntactic structure of a subclass of Relational adjectives, Th(ematic) adjectives within the framework of Distributed Morphology (Halle and Marantz 1993). Building on Bosque and Picallo’s (1996) classification of Relational
Mihaela Marchis
doaj  

On the Derivation of Denominal Adjectives in Polish

open access: yesStudies in Polish Linguistics
This research investigates the derivation of denominal qualitative adjectives in Polish formed by the suffixes ‑liwy, ‑ny, ‑sty, and ‑owy (e.g.
Sebastian Wasak
doaj   +1 more source

Home - About - Disclaimer - Privacy