Results 241 to 250 of about 3,228,785 (289)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Pilot clinical comparison of three occlusal splint fabrication techniques: A preliminary study. [PDF]

Sci Rep
Torné-Durán S, Marco-Martínez L, Serrano-Belmonte I.   +2 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Prenatal paracetamol exposure and wheezing in infancy: a targeted maximum likelihood estimation application. [PDF]

BMJ Open Respir Res
Moccia C, Zugna D, Popovic M, Moirano G, Pizzi C, Migliore E, Fariselli P, Sanavia T, Rusconi F, Nybo Andersen AM, Richiardi L, Maule M.   +11 more
europepmc   +1 more source

Predictors of adjustment to life after service among Canadian military veterans. [PDF]

Sci Rep
Waldhauser KJ, Hives BA, Liu Y, Puterman E, Beauchamp MR.   +4 more
europepmc   +1 more source

Synergistic Regulatory Effects of Water-Nitrogen Coupling on Osmotic Regulation, Yield, and Forage Quality of Alfalfa. [PDF]

Plants (Basel)
Ling Y, Yin M, Kang Y, Qi G, Ma Y.
europepmc   +1 more source

The effect of Indigenous American genomic ancestry on type 2 diabetes in Mexico: an analysis of 134 548 individuals from the Mexico City Prospective Study.

Lancet Public Health
Berumen J, Kuri-Morales P, Torres JM, Barrera E, Baca P, Rivas F, Ramirez-Tirado LA, Gonzalez-Carballo C, Zarza A, Del Vecchyo-Tenorio G, Pérez-Flores O, Pantoja-Melendez C, Ramírez R, Aguilar-Ramirez D, Friedrichs LG, Emberson JR, Alegre-Diaz J, Tapia-Conyer R.   +17 more
europepmc   +1 more source

Exploring resilience mechanism in learning burnout among pupils: school adjustment and academic self-efficacy. [PDF]

Front Psychol
Jiang C, Gao Q.
europepmc   +1 more source