Results 141 to 150 of about 6,386,978 (314)

The spectrum of adjustment disorders: too broad to be clinically helpful

, 2010
The clinical value of the current Diagnostic and Statistical Manual of Mental Disorders diagnosis of adjustment disorder is controversial.
Nicoletta Sonino, Sonino N., Federica Semprini, SEMPRINI F, FAVA, GIOVANNI ANDREA, SONINO, NICOLETTA, FAVA GA, SEMPRINI, FEDERICA, Giovanni Andrea Fava   +8 more
core   +1 more source

A Study of EffectiveFactors on Sleep Disorders in 4-6Years old Children in Tehran City, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Sleep pattern may changes over the lifetime,but the quantity and quality of sleep always depend on individual factors, such as age, gender, and psychological and environmental factors.
Giti Ozgoli, Zohreh Sheikhan, Farrin Soleimani, Maliheh Nasiri, Sahar Mirzaee, Fahimeh Kavousi, Tahereh Farokhi, Farahnaz Kholosi Badr   +7 more
doaj  

Urinary iodine levels and thyroid disorder prevalence in the adult population of China: a large-scale population-based cross-sectional study

Scientific Reports
In the past decade, the incidence of thyroid disorders has been steadily increasing, emerging as a prominent public health concern. Consequently, there is a growing interest in understanding the association between iodine nutritional status and thyroid ...
Xueqing Li, Mingluan Xing, Pengcheng Tu, Lizhi Wu, Huixia Niu, Manjin Xu, Yunfeng Xu, Zhe Mo, Xiaofeng Wang, Zhijian Chen   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Social adjustment and self-esteem in remitted patients with mood disorders

, 1999
Mood disorders are characterized by manic and depressive episodes alternating with normal mood. While social function is heavily impaired during episodes of illness, there are conflicting opinions about inter-episode function.
Mendlewicz, Julien, C Namia, D Souery, Lipp, Olivier, F Bauwens, Franchini, Linda, Smeraldi, Enrico, MC Cavallini, J Mendlewicz, Macciardi, Fabìo, Serretti, Alessandro, L Franchini, Souery, Daniel, Cavallini, Maria Cristina, O Lipp, A Serretti, F Macciardi, E Smeraldi, Namia, Caterina, Bauwens, Fabienne   +19 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Personality and individual differences among military conscripts diagnosed with adjustment, depressive, and anxiety disorders

, 2021
Mood and anxiety disorders represent some of the most prevalent mental disorders globally and this finding is evident within the military context as well.
Tan, Cindy Rui Min
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study.

, 2014
Inflammation is one possible mechanism underlying the associations between mental disorders and cardiovascular diseases (CVD). However, studies on mental disorders and inflammation have yielded inconsistent results and the majority did not adjust for ...
Merikangas, Kathleen, von Känel, R., Vandeleur, Caroline L, Castelao, Enrique, Aubry, J.M., Waeber, Gérard, Vollenweider, P., von Känel, Roland, Marques-Vidal, Pedro, Bovet, Pascal, Marques-Vidal, P., Mooser, V., Strippoli, M.P., Aubry, Jean-Michel, Lasserre, A.M., Bovet, P., Strippoli, Marie-Pierre F, Lasserre, Aurélie M, Preisig, M., Mooser, Vincent, Castelao, E., Merikangas, K., Gholam-Rezaee, Mehdi, Gholam-Rezaee, M., Preisig, Martin, Vollenweider, Peter, Glaus, J., Vandeleur, C.L., Glaus, Jennifer, Vandeleur, Caroline, Waeber, G.   +30 more
core   +1 more source