Results 131 to 140 of about 6,386,978 (314)

Workplace gender composition and long‐term sickness absence due to mental disorders: A retrospective cohort study

PCN Reports
Aim Long‐term sickness absence (LTSA) due to mental disorders is a public health concern. Workplace gender composition may influence employees' mental health outcomes; however, its impact on LTSA remains unclear.
Shohei Okura, Shinichi Iwasaki, Yasuhiko Deguchi, Yuki Kageyama, Kunio Maekubo, Ayaka Matsunaga, Koki Inoue   +6 more
doaj   +1 more source

ANXIETY DISORDERS IN ADOLESCENCE

, 2010
Adolescence is a time of significant change and identity development, particularly interpersonally. Although some activities do not directly predict future functioning, much that happens in adolescence can have significant implications for subsequent ...
Starr, LISA R., Davila, JOANNE, LA GRECA, ANNETTE M., Landoll, RYAN R.   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Adjustment Disorders Scoping Review - Studies on Suicide Outcomes Related to Adjustment Disorder in the U.S. Military between 2000-2024

Adjustment disorders are the most common mental health diagnosis in the U.S. military and rates of adjustment disorders have steadily increased in the last few years.
Madison Clark, Joan Wasserman, Dawnkimberly Hopkins, Megan Douglas, Jouhayna Bajjani-Gebara, Nathan Kearns, Margaux Finn Keller   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Parental rearing style as a predictor of attachment and psychosocial adjustment during young adulthood

, 2013
Parental rearing-styles are crucial for psychosocial adjustment both during childhood and adulthood. The current study examined whether: (a) parental rearing-styles predicted psychosocial adjustment in young-adulthood, (b) this relationship was mediated ...
Betts, LR, Stanbridge, A, Trueman, M, Chiverton, L, Stephens, J   +4 more
core   +1 more source

Suicidal Ideation by Selected Mental Health Conditions and Demographic Variables among Workers in a Large Non-Profit Organization in the United States

Health Behavior Research
This paper identifies rates of suicidal ideation by certain demographic variables and selected mental health conditions. Analyses utilize medical claims data for adult employees aged 18-64 years in a large corporation during 2017-2021.
McKay Ashton, Ray Merrill
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source