Results 111 to 120 of about 2,089,243 (278)

Basic Questions and Answers on Agricultural Adjustment [PDF]

[Answers to:] Why is National Agricultural Adjustment Necessary? What Is the Nation's Agricultural Policy? What Do Farmers Ask? What Was the Farmer’s Share? How Could One Surplus Cause Another? Why Did Farm Debts Increase?
Agricultural Adjustment Administration
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Somatic comorbidity assessment among patients with affective and adjustment disorders. [PDF]

, 2016
Aim of the study: Assess somatic comorbidity among patients with affective and adjustment disorders. Objectives: 1) To analyse association between adjustment, affective disorders and demographic characteristics. 2) To analyse association between comorbid
Mateikienė, Paula
core  

Suicidal Ideation by Selected Mental Health Conditions and Demographic Variables among Workers in a Large Non-Profit Organization in the United States

Health Behavior Research
This paper identifies rates of suicidal ideation by certain demographic variables and selected mental health conditions. Analyses utilize medical claims data for adult employees aged 18-64 years in a large corporation during 2017-2021.
McKay Ashton, Ray Merrill
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Urinary iodine levels and thyroid disorder prevalence in the adult population of China: a large-scale population-based cross-sectional study

Scientific Reports
In the past decade, the incidence of thyroid disorders has been steadily increasing, emerging as a prominent public health concern. Consequently, there is a growing interest in understanding the association between iodine nutritional status and thyroid ...
Xueqing Li, Mingluan Xing, Pengcheng Tu, Lizhi Wu, Huixia Niu, Manjin Xu, Yunfeng Xu, Zhe Mo, Xiaofeng Wang, Zhijian Chen   +9 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Study of EffectiveFactors on Sleep Disorders in 4-6Years old Children in Tehran City, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Sleep pattern may changes over the lifetime,but the quantity and quality of sleep always depend on individual factors, such as age, gender, and psychological and environmental factors.
Giti Ozgoli, Zohreh Sheikhan, Farrin Soleimani, Maliheh Nasiri, Sahar Mirzaee, Fahimeh Kavousi, Tahereh Farokhi, Farahnaz Kholosi Badr   +7 more
doaj