Results 71 to 80 of about 1,198,663 (392)

Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice

mAbs, 2021
The prevalence and societal impact of opioid use disorder (OUD) is an acknowledged public health crisis that is further aggravated by the current pandemic. One of the devastating consequences of OUD is opioid overdose deaths.
Bhupal Ban, Rodell C. Barrientos, Therese Oertel, Essie Komla, Connor Whalen, Megan Sopko, Yingjian You, Partha Banerjee, Agnieszka Sulima, Arthur E. Jacobson, Kenner C. Rice, Gary R. Matyas, Vidadi Yusibov   +12 more
doaj   +1 more source

Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer : a phase II trial [PDF]

, 2017
Background: Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC).
De Meerleer, Gert, Decaestecker, Karel, Dirix, Piet, Fonteyne, Valerie, Junius, Sara, Ost, Piet, Rammant, Elke, Swimberghe, Martijn   +7 more
core   +1 more source

Adjuvant Treatment of Melanoma [PDF]

ISRN Dermatology, 2011
Melanomas represent 4% of all malignant tumors of the skin, yet account for 80% of deaths from skin cancer.While in the early stages patients can be successfully treated with surgical resection, metastatic melanoma prognosis is dismal. Several oncogenes have been identified in melanoma as BRAF, NRAS, c-Kit, and GNA11 GNAQ, each capable of activating ...
Moreno Nogueira, J A, Valero Arbizu, M, Pérez Temprano, R   +2 more
openaire   +6 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Tracking Human Immunodeficiency Virus-1 Infection in the Humanized DRAG Mouse Model

Frontiers in Immunology, 2017
Humanized mice are emerging as an alternative model system to well-established non-human primate (NHP) models for studying human immunodeficiency virus (HIV)-1 biology and pathogenesis.
Jiae Kim, Jiae Kim, Kristina K. Peachman, Kristina K. Peachman, Ousman Jobe, Ousman Jobe, Elaine B. Morrison, Atef Allam, Atef Allam, Linda Jagodzinski, Sofia A. Casares, Mangala Rao   +11 more
doaj   +1 more source

Node-positive breast cancer: Which are the best chemotherapy regimens? [PDF]

, 2008
Breast cancer-associated mortality has been significantly reduced since the 1990s, mainly because of early diagnosis and systemic therapeutic interventions.
Bauerfeind, Ingo, Friese, Klaus, Harbeck, Nadia, Janni, Wolfgang, Rack, Brigitte, Sommer, Harald   +5 more
core   +2 more sources

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer.

JAMA Oncology, 2019
Importance Adjuvant chemotherapy in patients with stage III colon cancer prevents recurrence by eradicating minimal residual disease. However, which patients remain at high risk of recurrence after completing standard adjuvant treatment cannot currently ...
J. Tie, J. Cohen, Yuxuan Wang, M. Christie, K. Simons, Margaret Lee, R. Wong, S. Kosmider, S. Ananda, J. Mckendrick, Belinda Lee, J. Cho, I. Faragher, I. Jones, Janine Ptak, M. J. Schaeffer, Natalie Silliman, Lisa Dobbyn, Lu Li, C. Tomasetti, N. Papadopoulos, K. Kinzler, B. Vogelstein, P. Gibbs   +23 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Correction: Zika Virus-Derived E-DIII Protein Displayed on Immunologically Optimized VLPs Induces Neutralizing Antibodies without Causing Enhancement of Dengue Virus Infection. Vaccines 2019, 7, 72

Vaccines, 2020
The authors wish to make the following correction to their paper [...]
Gustavo Cabral-Miranda, Stephanie M. Lim, Mona O. Mohsen, Ilya V. Pobelov, Elisa S. Roesti, Matthew D. Heath, Murray A. Skinner, Matthias F. Kramer, Byron E.E Martina, Martin F. Bachmann   +9 more
doaj   +1 more source

Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer [PDF]

, 2016
Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC).
Ades, Felipe, Ahmed, Riz, Asher, Rebecca, Beresford, Mark, de Azambuja, Evandro, Gojis, Ondrej, Howell, Sacha J., Januszewski, Adam, Lewanski, Conrad, Lythgoe, Daniel, MacPherson, Iain R.J., Owadally, Waheeda, Palmieri, Carlo, Riddle, Pippa, Shah, Deep, Stanley, Barbara, Yan, Kelvin   +16 more
core   +1 more source