Results 141 to 150 of about 1,201,269 (362)

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT [PDF]

, 1963
B. B. Newbould
openalex   +1 more source

Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis

Advanced Science, EarlyView.
Hyaluronic acid Microneedles (MNs) are loaded with Sparfloxacin (SP) and zinc‐manganese sulfide (ZMS) for the postoperative in situ treatment of triple‐negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. These microneedles enhance antitumor immunity by activating the cGAS‐STING pathway, suppress tumor growth, reduce ...
Zhaoyou Chu, Wang Zheng, Wanyue Fu, Jun Liang, Wanni Wang, Lingling Xu, Xiaohua Jiang, Zhengbao Zha, Haisheng Qian   +8 more
wiley   +1 more source

Adjuvant chemotherapy, not radiotherapy, prolongs survival for node-negative non–small cell lung cancer with positive surgical marginsCentral MessagePerspective

JTCVS Open, 2023
Objective: The study objective was to determine differences in survival depending on adjuvant therapy type, timing, and sequence in node-negative disease with positive margins after non–small cell lung cancer resection.
Arman Ashrafi, BA, Jeremy Yu, MS, Alexander T. Kim, BA, Jason C. Ye, MD, Elizabeth A. David, MD, Sean C. Wightman, MD, Scott M. Atay, MD, Takashi Harano, MD, Anthony W. Kim, MD, MS   +8 more
doaj  

A Large Language Model Pipeline for Breast Cancer Oncology [PDF]

arXiv
Large language models (LLMs) have demonstrated potential in the innovation of many disciplines. However, how they can best be developed for oncology remains underdeveloped. State-of-the-art OpenAI models were fine-tuned on a clinical dataset and clinical guidelines text corpus for two important cancer treatment factors, adjuvant radiation therapy and ...
arxiv  

Efficacy of adjuvant chemotherapy for small bowel adenocarcinoma: A propensity score–matched analysis

Cancer, 2016
The role of adjuvant chemotherapy (AC) in the treatment of small bowel adenocarcinoma is poorly defined. Previous analyses have been limited by small sample sizes and have failed to demonstrate a survival advantage.
B. Ecker, M. McMillan, J. Datta, R. Mamtani, B. Giantonio, D. Dempsey, D. Fraker, J. Drebin, G. Karakousis, R. Roses   +9 more
semanticscholar   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial

JAMA Oncology, 2017
Importance Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI) are prognostic for survival in many cancers and for resistance to fluoropyrimidines in early colon cancer.
E. Smyth, A. Wotherspoon, C. Peckitt, David Gonzalez, Sanna Hulkki-Wilson, Z. Eltahir, M. Fassan, M. Rugge, N. Valeri, A. Okines, M. Hewish, W. Allum, S. Stenning, M. Nankivell, R. Langley, D. Cunningham   +15 more
semanticscholar   +1 more source

Adjuvant Chemotherapy of Osteogenic Sarcoma: Progress and Perspectives 4 [PDF]

, 1978
Emil Frei, Norman Jaffe, M. Gero, Howard E. Skipper, Hugh G. Watts   +4 more
openalex   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Model for tumour growth with treatment by continuous and pulsed chemotherapy [PDF]

arXiv, 2013
In this work we investigate a mathematical model describing tumour growth under a treatment by chemotherapy that incorporates time-delay related to the conversion from resting to hunting cells. We study the model using values for the parameters according to experimental results and vary some parameters relevant to the treatment of cancer.
arxiv