Results 121 to 130 of about 204,124 (382)

Development and Regulation of Novel Influenza Virus Vaccines: A United States Young Scientist Perspective

open access: yesVaccines, 2018
Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the ...
Surender Khurana
doaj   +1 more source

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo [PDF]

open access: yes, 2018
Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity.
Baz Morelli, Adriana   +10 more
core   +3 more sources

Improving organ dose sparing in left‐sided breast cancer with yaw‐limited volumetric modulated arc therapy: A dosimetric comparison to conventional and intensity modulated radiation therapy approaches

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background To assess the dose‐sparing capabilities of a yaw‐limited volumetric modulated arc therapy (YL_VMAT) beam setup for adjacent organs at risk (OAR) in comparison with 3D‐conventional radiation therapy (3D‐CRT), intensity‐modulated radiation therapy (IMRT) and conventional VMAT for radiation therapy in left‐sided breast cancer patients.
Gerhard Pollul   +4 more
wiley   +1 more source

Virus-Like Particle (VLP) Plus Microcrystalline Tyrosine (MCT) Adjuvants Enhance Vaccine Efficacy Improving T and B Cell Immunogenicity and Protection against Plasmodium berghei/vivax

open access: yesVaccines, 2017
Vaccination is the most effective prophylactic tool against infectious diseases. Despite continued efforts to control malaria, the disease still generally represents a significant unmet medical need.
Gustavo Cabral-Miranda   +11 more
doaj   +1 more source

On null hypotheses in survival analysis [PDF]

open access: yesarXiv, 2018
The conventional nonparametric tests in survival analysis, such as the log-rank test, assess the null hypothesis that the hazards are equal at all times. However, hazards are hard to interpret causally, and other null hypotheses are more relevant in many scenarios with survival outcomes.
arxiv  

Stereotactic radiosurgery for multiple small brain metastases using gamma knife versus single‐isocenter VMAT: Normal brain dose based on lesion number and size

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The study evaluates rapid linear accelerator (Linac) single isocenter stereotactic radiosurgery (SRS) with Hyperarc for large target numbers. We compared to Gamma Knife (GK), which suffers from long treatment times and investigated causes of differences. Methods Linac SRS and GK treatment plans for patients receiving 18 Gy to the gross
Abram Abdou   +4 more
wiley   +1 more source

COMPARATIVE IMMUNOGENICITY STUDIES OF ADJUVANTS FROM VARIOUS SOURCES AND WITH DIFFERENT MECHANISMS OF ACTION FOR INACTIVATED INFLUENZA VACCINES

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Direct immunogenicity comparison of adjuvants from various sources and with different mechanisms of action for inactivated influenza vaccines. Materials and methods.
M. I Chernikova   +2 more
doaj  

Mucosal Vaccination via the Respiratory Tract

open access: yesPharmaceutics, 2019
Vaccine delivery via mucosal surfaces is an interesting alternative to parenteral vaccine administration, as it avoids the use of a needle and syringe. Mucosal vaccine administration also targets the mucosal immune system, which is the largest lymphoid ...
Marie Hellfritzsch, Regina Scherließ
doaj   +1 more source

Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults [PDF]

open access: yes, 2016
Background: Non-typeable Haemophilus influenzae (NTHi) is a major cause of various respiratory diseases. The development of an effective vaccine against NTHi mandates new approaches beyond conjugated vaccines as this opportunistic bacterium is non ...
Aris, Emmanuel   +7 more
core   +2 more sources

Are Thousands of Samples Really Needed to Generate Robust Gene-List for Prediction of Cancer Outcome? [PDF]

open access: yesarXiv, 2016
The prediction of cancer prognosis and metastatic potential immediately after the initial diagnoses is a major challenge in current clinical research. The relevance of such a signature is clear, as it will free many patients from the agony and toxic side-effects associated with the adjuvant chemotherapy automatically and sometimes carelessly subscribed
arxiv  

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