Results 131 to 140 of about 213,598 (380)

Development and Regulation of Novel Influenza Virus Vaccines: A United States Young Scientist Perspective

Vaccines, 2018
Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the ...
Surender Khurana
doaj   +1 more source

Advantages and limitations of navigation‐based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard, Simon J. P. Meara, Ehab M. Ibrahim, Carl G. Rowbottom   +3 more
wiley   +1 more source

Basic Properties and Development Status of Aluminum Adjuvants Used for Vaccines

Vaccines
Background: Aluminum adjuvants, renowned for their safety and efficacy, act as excellent adsorbents and vaccine immunogen enhancers, significantly contributing to innate, endogenous, and humoral immunity.
Jingyang Lan, Disong Feng, Xueshan He, Qianru Zhang, Rong Zhang   +4 more
doaj   +1 more source

Virus-Like Particle (VLP) Plus Microcrystalline Tyrosine (MCT) Adjuvants Enhance Vaccine Efficacy Improving T and B Cell Immunogenicity and Protection against Plasmodium berghei/vivax

Vaccines, 2017
Vaccination is the most effective prophylactic tool against infectious diseases. Despite continued efforts to control malaria, the disease still generally represents a significant unmet medical need.
Gustavo Cabral-Miranda, Matthew D. Heath, Mona O. Mohsen, Ariane C. Gomes, Paul Engeroff, Amy Flaxman, Fabiana M. S. Leoratti, Aadil El-Turabi, Arturo Reyes-Sandoval, Murray A. Skinner, Matthias F. Kramer, Martin F. Bachmann   +11 more
doaj   +1 more source

On null hypotheses in survival analysis [PDF]

arXiv, 2018
The conventional nonparametric tests in survival analysis, such as the log-rank test, assess the null hypothesis that the hazards are equal at all times. However, hazards are hard to interpret causally, and other null hypotheses are more relevant in many scenarios with survival outcomes.
arxiv  

Studies on the Adjuvant Action of Bacterial Endotoxins on Antibody Formation [PDF]

, 1959
Phyllis D. Kind, Arthur G. Johnson
openalex   +1 more source

Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem, Bali Pulendran, Rino Rappuoli, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Dosimetric evaluation and clinical application of collimated apertures with proton beam line scanning in stereotactic radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Stereotactic radiotherapy (SRT) is a highly effective treatment with precision for small, localized lesions. Proton therapy, characterized by the Bragg peak, offers superior dose conformity compared to photon‐based approaches. However, challenges remain in minimizing lateral penumbra and optimizing dose delivery, particularly for small
Chen‐Yu Chou, Hsiao‐Chieh Huang, Shen‐Hao Lee, Shih‐Ming Hsu   +3 more
wiley   +1 more source

Progress and prospect of polysaccharides as adjuvants in vaccine development

Virulence
Vaccines are an effective approach to confer immunity against infectious diseases. Modern subunit vaccines offer more precise target and safe protection compared to traditional whole-pathogen vaccines.
Xinlong Liang, Jiaying Zhou, Mengmeng Wang, Jing Wang, Houhui Song, Yigang Xu, Yuan Li   +6 more
doaj   +1 more source

Mucosal Vaccination via the Respiratory Tract

Pharmaceutics, 2019
Vaccine delivery via mucosal surfaces is an interesting alternative to parenteral vaccine administration, as it avoids the use of a needle and syringe. Mucosal vaccine administration also targets the mucosal immune system, which is the largest lymphoid ...
Marie Hellfritzsch, Regina Scherließ
doaj   +1 more source