Results 81 to 90 of about 213,598 (380)

Making accurate and interpretable treatment decisions for binary outcomes [PDF]

arXiv, 2023
Optimal treatment rules can improve health outcomes on average by assigning a treatment associated with the most desirable outcome to each individual. Due to an unknown data generation mechanism, it is appealing to use flexible models to estimate these rules. However, such models often lead to complex and uninterpretable rules.
arxiv  

Caffeine Modulates the Dynamics of DODAB Membranes: Role of the Physical State of the Bilayer [PDF]

, 2020
Caffeine (1,3,7-trimethylxanthine), an ingredient of coffee, is used worldwide as a psychostimulant, antioxidant, and adjuvant analgesic. To gain insights into the action mechanism of caffeine, we report on its effects on the phase behaviour and microscopic dynamics of a dioctadecyldimethylammonium bromide (DODAB) lipid membrane, as studied ...
arxiv   +1 more source

Effect of adjuvants on the efficiency of dimethomorph plus mancozeb (Acrobat 2 kg:ha) on the control of late blight [PDF]

, 2007
Industrial adjuvants were tested in combination with dimethomorph plus mancozeb (Acrobat 2 kg/ha) in the field to investigate their efficacy on foliar late blight caused by Phytophthora infestans.
Haesaert, Geert, Heremans, Betty, Isebaert, Sofie, Ryckaert, Bert, Spanoghe, Pieter, Steurbaut, Walter, Verhoeven, Ruth   +6 more
core   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

A comparison of cancer vaccine adjuvants in clinical trials

Cancer Treatment and Research Communications, 2023
Cancer treatment has come a long way in increasing overall survival; however, evasion of the immune system continues to be a challenge in treating individuals with established disease burdens.
Morgan Marriott, Brittany Post, Lipika Chablani   +2 more
doaj  

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source

Alum adjuvant: some of the tricks of the oldest adjuvant

Journal of Medical Microbiology, 2012
Alum has been the most widely used adjuvant for over 80 years. Although there have been searches for alternative adjuvants, aluminium-containing adjuvants will continue to be used for many years due to their good track record of safety, low cost and adjuvanticity with a variety of antigens.
Kaat Fierens, Mirjam Kool, Bart N. Lambrecht   +2 more
openaire   +4 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Study on novel vaccines and adjuvants for rabbit infectious diseases

World Rabbit Science
Epidemic diseases have seriously damaged the development of the global rabbit industry. Vaccination plays a vital role in improving the health and welfare of livestock and preventing animal-tohuman transmission, thereby constituting a major public health
Yee Huang, Xuemei Cui, Zizhe Hu, Quanan Ji, Yan Liu, Guolian Bao   +5 more
doaj   +1 more source

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference

Frontiers in Immunology, 2020
Other than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped.
Dheeraj Soni, Dheeraj Soni, Simon D. Van Haren, Simon D. Van Haren, Olubukola T. Idoko, Olubukola T. Idoko, Jay T. Evans, Joann Diray-Arce, Joann Diray-Arce, Joann Diray-Arce, David J. Dowling, David J. Dowling, Ofer Levy, Ofer Levy, Ofer Levy   +14 more
doaj   +1 more source