Results 171 to 180 of about 67,869 (296)

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

open access: yesBritish Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier   +9 more
wiley   +1 more source

Myofibroblast‐Like CAFs in Metastatic Lymph Nodes Drive Tumor Stemness and Poor Prognosis in Head and Neck Cancer

open access: yesCancer Science, EarlyView.
Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hiroyuki Hagiwara   +8 more
wiley   +1 more source

Influence of adrenomedullin on the enzymatic activity of dipeptidyl peptidase 3 <i>in vitro</i>. [PDF]

open access: yesJ Enzyme Inhib Med Chem
Nissen R   +6 more
europepmc   +1 more source

ADM-Aeolus - ESA´s wind profile lidar and its contribution to numerical weather prediction and climate research [PDF]

open access: yes, 2010
Riishojgaard, L.-P.   +19 more
core  

Clusterix: A Hybrid Visualization Model for Hierarchically Clustered Networks

open access: yesComputer Graphics Forum, EarlyView.
Abstract We introduce Clusterix, a novel hybrid visualization model for representing hierarchically clustered networks, which also supports directed and weighted edges. Clusterix offers an integrated view of both the network and its full cluster hierarchy by compactly visualizing the cluster inclusion tree enriched with links of the network.
Carla Binucci   +6 more
wiley   +1 more source

Atlantic trade and the West African market economy: New evidence from cowry imports, 1650–1905

open access: yesThe Economic History Review, EarlyView.
Abstract Between the seventeenth and twentieth centuries, billions of cowries arrived in West Africa, leaving one of the few quantitative traces available for historians to measure the Atlantic trade's impact on the precolonial market economy. Yet, current estimates substantially underestimate the volume of cowry imports.
María José Pont Cháfer
wiley   +1 more source

Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma. [PDF]

open access: yesCell Oncol (Dordr)
Zhang X   +9 more
europepmc   +1 more source

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