Results 201 to 210 of about 31,497 (236)
Some of the next articles are maybe not open access.
Bioluminescent assays for ADMET
Expert Opinion on Drug Metabolism & Toxicology, 2007Bioluminescent assays couple a limiting component of a luciferase-catalyzed photon-emitting reaction to a variable parameter of interest, while holding the other components constant or non-limiting. In this way light output varies with the parameter of interest.
James J, Cali +5 more
openaire +2 more sources
2016
Drug discovery and development is a costly and time-consuming endeavor (Calcoen et al. Nat Rev Drug Discov 14(3):161-162, 2015; The truly staggering cost of inventing new drugs. Forbes. http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/, 2012; Scannell et al.
Jayeeta, Ghosh +4 more
openaire +2 more sources
Drug discovery and development is a costly and time-consuming endeavor (Calcoen et al. Nat Rev Drug Discov 14(3):161-162, 2015; The truly staggering cost of inventing new drugs. Forbes. http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/, 2012; Scannell et al.
Jayeeta, Ghosh +4 more
openaire +2 more sources
ADMET reactions in miniemulsion
Journal of Polymer Science Part A: Polymer Chemistry, 2014ABSTRACTThis work investigates acyclic diene metathesis (ADMET) polymerization reactions in aqueous miniemulsion. Different types of ruthenium‐based catalysts and different surfactants (anionic, cationic, and nonionic) were evaluated. A Ru‐indenylidene catalyst (Umicore M2) showed higher activity in water if compared to the Ru‐benzylidene catalysts ...
Cardoso, Priscilla B. +5 more
openaire +3 more sources
2016
The use of acyclic diene metathesis (ADMET) in the synthesis of functionalized polyolefins is discussed. The nature of polymerizations, catalysts, and techniques are briefly covered. An overview of recent functionalized ADMET polymers and major contributions to its methodology is given.
Taylor W Gaines +2 more
openaire +1 more source
The use of acyclic diene metathesis (ADMET) in the synthesis of functionalized polyolefins is discussed. The nature of polymerizations, catalysts, and techniques are briefly covered. An overview of recent functionalized ADMET polymers and major contributions to its methodology is given.
Taylor W Gaines +2 more
openaire +1 more source
Industrial applications of in silico ADMET
Journal of Molecular Modeling, 2014Quantitative structure activity relationship (QSAR) modeling has been in use for several decades now. One branch of it, in silico ADMET, became more and more important since the late 1990s as studies indicated that poor pharmacokinetics and toxicity were important causes of costly late-stage failures in drug development.
Bernd, Beck, Tim, Geppert
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ADMET—turning chemicals into drugs
Nature Biotechnology, 2001Rapidly resolving the pharmacokinetic and toxicological properties of drug candidates remains a key challenge for drug developers.
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QM Calculations in ADMET Prediction
2020In recent years, there has been an increase in the application of quantum mechanics (QM) methods to describe properties related to the ADMET profile of small molecules. The application of these methods allows calculating useful descriptors and physiochemical properties contributing to ADMET prediction.
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ADMETboost: a web server for accurate ADMET prediction
Journal of Molecular Modeling, 2022Peng Tao
exaly
Lipophilicity and ADMET Analysis of Quinoline-1,4-quinone Hybrids
Pharmaceutics, 2023Ewa Bebenek +2 more
exaly