Results 21 to 30 of about 31,497 (236)

Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive ADMET, docking and simulation studies

Frontiers in Pharmacology, 2022
Graphical ...
Syed Shams ul Hassan, Syed Shams ul Hassan, Syed Qamar Abbas, Ishaq Muhammad, Ishaq Muhammad, Jia-Jia Wu, Jia-Jia Wu, Shi-Kai Yan, Shi-Kai Yan, Fawad Ali, Muhammad Majid, Hui-Zi Jin, Hui-Zi Jin, Simona Bungau   +13 more
doaj   +1 more source

Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioactive
Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia   +7 more
doaj   +1 more source

Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

Hittite Journal of Science and Engineering, 2023
In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other.
Ergin Murat Altuner, Muhammet Çavuş, İzzet Şener, Merve Şenturan, Çiğdem Şahin, Nesrin Şener, Eda Altınöz, Merve Zurnacı, Mahmut Gür   +8 more
doaj   +1 more source

Chromatographic technique to support ADMET&DMPK in early drug discovery [PDF]

, 2018
The drug discovery process usually involves the discovery of a potent new chemical entity which has shown some activity on a target that is believed to be relevant in a certain type of disease.
Klara Valko, Valko, Klara, Klara Livia Valko   +2 more
core   +1 more source

Stability and computational analyses of selected pesticides in use in the Republic of Serbia [PDF]

Journal of the Serbian Chemical Society
Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated.
Arsić Biljana, Petrović Stefan, Mrmošanin Jelena, Dimitrijević Ivana, Tošić Snežana, Stojanović Gordana, Glišić Sanja, Milićević Jelena   +7 more
doaj   +1 more source

Insights into the molecular basis of some chalcone analogues as potential inhibitors of Leishmania donovani: An integrated in silico and in vitro study

Open Chemistry, 2022
Protozoal infections caused by species belonging to Leishmania donovani complex are responsible for the most severe form of leishmaniasis, especially in Sudan and other developing countries.
Osman Marwa S., Awad Talal A., Shantier Shaza W., Garelnabi Elrashied A. E., Mukhtar Moawia M., Osman Wadah, Mothana Ramzi A., Elhag Rashid I.   +7 more
doaj   +1 more source

Inhibitors of α-glucosidase and Angiotensin-converting Enzyme in the Treatment of Type 2 Diabetes and its Complications: A Review on in Silico Approach

Pharmaceutical and Biomedical Research, 2022
Background: The use of pharmacological agents to synergistically target key enzymes associated with carbohydrate digestion (α-glucosidase) and the hypertension-related angiotensin-converting enzyme (ACE) are critical strategies for the management of type
Oyedele Abdul-Quddus Kehinde, Boyenle Ibrahim Damilare, AbdeenTunde Ogunlana, Ashiru Mojeed Ayoola, Atanda Opeyemi Emmanuel, Adelusi Temitope Isaac   +5 more
doaj  

Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: A Computational drug design approach

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundIn the last couple of years, viral infections have been leading the globe, considered one of the most widespread and extremely damaging health problems and one of the leading causes of mortality in the modern period.
Shopnil Akash, Arafat Hossain, Md. Sarowar Hossain, Md. Mominur Rahman, Mohammad Z. Ahmed, Nemat Ali, Martin Valis, Kamil Kuca, Kamil Kuca, Rohit Sharma   +9 more
doaj   +1 more source

A promising computational study of ovarian cancer treatment of the isolated compound 5,7-dihydroxy-3(R)-methylphthalide [PDF]

Journal of HerbMed Pharmacology
Introduction: Ovarian cancer is a serious disease with high incidence and mortality in women, despite advances in surgical and medical therapies. Continuous efforts to develop safer and more effective treatments are crucial.
Agus Dwi Ananto, Tendy Oktriawan, Kasta Gurning, Muhammad Idham Darussalam Mardjan, Tri Joko Raharjo, Yoshihito Shiono, Winarto Haryadi   +6 more
doaj   +1 more source

Antidiabetic potential of Sapindus trifoliatus fruit ethanolic extract: Gas chromatography–mass spectrometry profiling, molecular docking, and in vitro/in vivo evaluation

Journal of Advanced Pharmaceutical Technology & Research
Diabetes mellitus causes vascular, renal, and ocular complications. In this study, we evaluated an ethanolic extract of Sapindus trifoliatus fruit using gas chromatography–mass spectrometry (GC-MS) profiling, molecular docking, and in vitro and in vivo ...
Sarita Rawat, Prashant Kumar Dhakad, Ritu Gilhotra, Kavita Goyal, A. Rekha, Mohit Rana, Rakhi Mishra, Lakshmi Thangavelu, Gaurav Gupta   +8 more
doaj   +1 more source