Results 41 to 50 of about 31,497 (236)

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Theoretical ADMET characters.

, 2022
Theoretical ADMET characters.
Ibrahim H. Eissa (10145861), Eslam B. Elkaeed (9952518), Mohammed S. Taghour (10899404), Dalal Z. Husein (13851134), Hazem Elkady (10899422), Wagdy M. Eldehna (4260952), Nehal El-Deeb (4874308), Ahmed M. Kenawy (9014507), Bshra A. Alsfouk (13259895), Mohamed S. Alesawy (11931303), Ahmed M. Metwaly (9675265)   +10 more
core   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

EQUIPMENT WITH HYDROSTATIC AMPLIFIER MODELED 3D

Journal of Industrial Design and Engineering Graphics, 2013
The equipment with hydrostatic amplifier is a new constructive solution modeled 3D using NX 7.5 software. Hydraulic equipment allows the amplification of a constant torque of a DC electric motor of low power at a variable speed.
EFTIMIE Dorin, FRONE Alexandru
doaj  

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Predicted ADMET properties of Ashwagandhanolide.

, 2022
Predicted ADMET properties of Ashwagandhanolide.
Kestur Nagaraj Amruthesh (13919494), Shiva Prasad Kollur (10038272), Norma Flores-Holguín (5511347), Hittanahallikoppal Gajendramurthy Gowtham (13919476), Daniel Glossman-Mitnik (3765649), Victor Stupin (12378552), Raghu Ram Achar (12378555), Chandan Shivamallu (11532166), Juan Frau (1987492), Ekaterina Silina (12378549), Mahadevamurthy Murali (13919479), Sushma Pradeep (10038266), Satish Anandan (13919488), Joaquín Ortega-Castro (11532163), Sudarshana Brijesh Singh (13919482), Anjana Thampy (13919491), C. S. Shivakumar (13919485)   +16 more
core   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

The Theoretical Substantiation of the Targeted Search for New DPP4 Inhibitors. Computational Studies of Potential Candidates

Журнал органічної та фармацевтичної хімії
Growing evidence suggests that dipeptidyl peptidase 4 (DPP4) inhibitors, in addition to their role in improving glycemic control, help to reduce endothelial dysfunction and have hypolipidemic, anti-atherosclerotic, antitumor, antiviral, and neurotropic ...
Marharyta M. Suleiman, Аnton P. Semenets, Nataliia P. Kobzar, Lina O. Perekhoda   +3 more
doaj   +1 more source

Stress degradation, structural optimization, molecular docking, ADMET analysis of tiemonium methylsulphate and its degradation products

Journal of Taibah University for Science, 2020
Attempts have been taken to study stress degradation of tiemonium methylsulphate (TMS). Quantum mechanical approach was applied to investigate the structural information, protein binding affinity and pharmacokinetic properties of the TMS and degradation ...
Mohammad Nasir Uddin, Monir Uzzaman, Suman Das, Md. Al-Amin, Md. Nazmul Haque Mijan   +4 more
doaj   +1 more source

ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries

Bioinformatics, 2023
Abstract Motivation The emergence of large chemical repositories and combinatorial chemical spaces, coupled with high-throughput docking and generative AI, have greatly expanded the chemical diversity of small molecules for drug discovery.
Kyle Swanson, Parker Walther, Jeremy Leitz, Souhrid Mukherjee, Joseph C. Wu, Rabindra V. Shivnaraine, James Zou   +6 more
openaire   +4 more sources