Results 61 to 70 of about 96,143 (246)

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach

Open Veterinary Journal
Background: Lumpy skin disease (LSD) is a transboundary virus disease that mostly affects cattle. It has recently reported all over the world, which highlights the need for efficient control methods. LSD poses serious economic dangers worldwide. Aim:
S. Vamshi Krishna, Aniket Sarkar, Suchandan Banerjee, Anindya Sundar Panja   +3 more
doaj   +1 more source

Radiative Transfer Limits of Two-Frequency Wigner Distribution for Random Parabolic Waves [PDF]

, 2006
The present note establishes the self-averaging, radiative transfer limit for the two-frequency Wigner distribution for classical waves in random media. Depending on the ratio of the wavelength to the correlation length the limiting equation is either a ...
Albert C. Fannjiang, Blomgren, Derode, Derode, Fannjiang, Fannjiang, Fannjiang, Fannjiang, Fannjiang, Ishimaru, Mishchenko, Ryzhik   +11 more
core   +8 more sources

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioactive
Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia   +7 more
doaj   +1 more source

A kinetic eikonal equation [PDF]

, 2012
We analyse the linear kinetic transport equation with a BGK relaxation operator. We study the large scale hyperbolic limit $(t,x)\to (t/\eps,x/\eps)$. We derive a new type of limiting Hamilton-Jacobi equation, which is analogous to the classical eikonal ...
Bouin, Emeric, Calvez, Vincent
core   +6 more sources

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari, Mohamed‐Amine Jabri, Imen Hammami, Hichem Sebai   +3 more
wiley   +1 more source

$\mathcal{G}$-SELC: Optimization by sequential elimination of level combinations using genetic algorithms and Gaussian processes

, 2009
Identifying promising compounds from a vast collection of feasible compounds is an important and yet challenging problem in the pharmaceutical industry.
Mandal, Abhyuday, Ranjan, Pritam, Wu, C. F. Jeff   +2 more
core   +1 more source

Holomorphic vector bundles on non-algebraic surfaces [PDF]

, 2002
The existence problem for holomorphic structures on vector bundles over non-algebraic surfaces is in general still open. We solve this problem in the case of rank 2 vector bundles over K3 surfaces and in the case of vector bundles of arbitrary rank over ...
Teleman, Andrei, Toma, Matei
core   +6 more sources

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source