Results 81 to 90 of about 96,143 (246)

In Silico Studies of a Novel Scaffold of Acetylsalicylic Acid Derivatives Against EGFR by Molecular Docking and Molecular Dynamics Simulations

Cumhuriyet Science Journal
In this study, a molecular docking study was performed to propose the acetylsalicylic acid derivative 2-[(4-Acetylphenyl)carbamoyl]phenyl acetate (AMPBS) as a potential cancer candidate targeting the Epidermal Growth Factor Receptor (EGFR).
Alpaslan Bayrakdar
doaj   +1 more source

Measure boundary value problem for semilinear elliptic equations with critical Hardy potentials [PDF]

, 2014
Let $\Omega\subset\BBR^N$ be a bounded $C^2$ domain and $\CL_\gk=-\Gd-\frac{\gk}{d^2}$ the Hardy operator where $d=\dist (.,\prt\Gw)$ and $00$ is that $\gm$ is absolutely continuous with respect to the capacity associated to the Besov space $B^{2-\frac{2+
Gkikas, Konstantinos, Veron, Laurent
core   +2 more sources

Very nilpotent basis and n-tuples in Borel subalgebras [PDF]

, 2010
A (vector space) basis B of a Lie algebra is said to be very nilpotent if all the iterated brackets of elements of B are nilpotent. In this note, we prove a refinement of Engel's Theorem.
Michael, Bulois
core   +5 more sources

Thermally Bistable Stiff Stilbene Photoswitches and Polymer Applications

The Chemical Record, EarlyView.
Thermally stable photoswitches offer new opportunities for controlling polymer structures and functions under nonequilibrium conditions. This Personal Account highlights stiff stilbene (SS) and sterically hindered stiff stilbene (HSS) photoswitches, which combine large structural changes with exceptional thermal bistability.
Keiichi Imato
wiley   +1 more source

Computational exploration of nigerian bioactive compounds as potential inhibitors of septic shock

Universitas Scientiarum
Septic shock is a fatal medical condition characterized by severe hypotension or elevated lactate levels as a consequence of sepsis. Septic shock occurs as a result of pathogenic bacterial and viral infections.
Yemisi Elizabeth Asibor, Dayo Felix Latona, Banjo Semire   +2 more
doaj   +1 more source

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor [PDF]

, 2014
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which ...
Agbaba, D., Alcaro, S., Bautista-Aguilera, O.M., Chioua, M., De Andrés, L., Filipic, S., Marco-Contelles, J., Nikolic, K., Ortuso, F., Ramsay, R.R., Rodríguez-Franco, M.I., Samadi, A., Soriano, E., Yañez, M.   +13 more
core   +3 more sources

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Inhibitors of α-glucosidase and Angiotensin-converting Enzyme in the Treatment of Type 2 Diabetes and its Complications: A Review on in Silico Approach

Pharmaceutical and Biomedical Research, 2022
Background: The use of pharmacological agents to synergistically target key enzymes associated with carbohydrate digestion (α-glucosidase) and the hypertension-related angiotensin-converting enzyme (ACE) are critical strategies for the management of type
Oyedele Abdul-Quddus Kehinde, Boyenle Ibrahim Damilare, AbdeenTunde Ogunlana, Ashiru Mojeed Ayoola, Atanda Opeyemi Emmanuel, Adelusi Temitope Isaac   +5 more
doaj  

Analytical smoothing effect of solution for the boussinesq equations

, 2017
In this paper, we study the analytical smoothing effect of Cauchy problem for the incompressible Boussinesq equations. Precisely, we use the Fourier method to prove that the Sobolev H 1-solution to the incompressible Boussinesq equations in periodic ...
Cheng, F, Xu, C. -J
core   +1 more source

Two Remarks on Kaehler Homogeneous Manifolds [PDF]

, 2007
We prove that every Kaehler solvmanifold has a finite covering whose holomorphic reduction is a principal bundle. An example is given that illustrates the necessity, in general, of passing to a proper covering.
Gilligan, Bruce, Oeljeklaus, Karl
core   +3 more sources