Results 91 to 100 of about 31,497 (236)

Sesquiterpene‐Rich Essential Oil From Magnolia officinalis Stem Bark: Chemical Composition, Biological Activities, and In Silico Approach

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The essential oil from Magnolia officinalis (M. officinalis) stem bark, rich in sesquiterpenes, exhibited multiple bioactivities including cytotoxic, antioxidant, α‐glucosidase inhibitory, anti‐inflammatory, and antimicrobial effects, which were further supported by molecular docking analysis.
Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Tran Quang Hai, Le The Hoai, Le Ba Vinh, Pham Minh Quan, Nguyen Dinh Luyen, Ninh The Son   +8 more
wiley   +1 more source

Computational identification and analysis of CNP0269688 as a natural product inhibitor disrupting the interaction between the HIV matrix domain and tRNA

Frontiers in Chemistry
Our research is dedicated to combating HIV by targeting its Matrix (MA) domain, which is crucial for viral assembly and replication. This strategy specifically aims to interrupt early-stage infection and deter drug resistance by focusing on this ...
Chengjie Xu, Songtao Wu, Pengju Liu, Yao Huang, Yuchao Chen, Guoping Ding, Guoping Ding, Shengnan Jia, Shengnan Jia   +8 more
doaj   +1 more source

In Silico and In Vitro Evaluation of Atriplex halimus: Antibacterial Activity, Molecular Docking, ADMET Profiling, and Cytotoxicity Assessment

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Atriplex halimus aqueous and hydroethanolic extracts, rich in trans‐cinnamic acid, catechin, epigallocatechin, and vitamin C. The Extracts showed modest antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and dose‐dependent cytotoxicity in Artemia salina.
Mohammed Roubi, Ayoub Farihi, Mohammed Dalli, Salah‐eddine Azizi, Raffaele Conte, Mohammed F. Hawaal, Abdullah R. Alonazi, Amama Rani, Bonglee Kim, Nadia Gseyra, Ramzi A. Mothana   +10 more
wiley   +1 more source

VALUATION OF THE ANTI-LEISHMANIAL POTENTIAL OF SOME PROMINENT LEAD COMPOUNDS AGAINST PYRIDOXAL KINASE IN COMPLEX WITH ADENOSINE DIPHOSPHATE AND PYRIDOXINE: A COMPARATIVE STUDY [PDF]

Acta Scientifica Malaysia
More than twelve million individuals globally suffer from leishmaniasis, and an additional billion people are at risk in leishmaniasis prevalent areas. This work was motivated by the need to create drugs with high efficacies against leishmaniasis and to ...
Fabian Audu Ugbe, Abdullahi Muhammad Ayuba, Emmanuel Israel Edache, Anne Jibrin, Oluwagbemiga Tayo Amusan   +4 more
doaj   +1 more source

Combining Phytochemical and Computational Approach on Citrus hystrix DC. (Kaffir Lime) Peel Extract: Anti‐Diabetic and Anti‐Inflammatory Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Citrus hystrix DC. (kaffir lime) peel was dried and subjected to ethanolic extract. The GC‐MS analysis showed the presence of significant phyto‐ingredients. Pharmacokinetic and ADMET filters were applied to major constituents, and molecular docking, Gene Ontology (GO), and KEGG pathway enrichment analyses on mechanistic plausibility were also performed.
Malathy Soundara Rajan, Sankarganesh Palaniyandi, Swetha Sunkar   +2 more
wiley   +1 more source

Eriosema glomeratum Possessed Interesting Bioactive Constituents and Semisynthetic Derivatives With Relevant Biosynthetic Correlation and Important Chemophenetic Significance

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A medicinal plant Eriosema glomeratum has potentially lead compounds, erioschalcones A and B, and their semisynthetic derivatives for drug discovery. ABSTRACT Plants are sources of compounds with benefits in human health and animal well‐being. Plant‐based foods may contain huge numbers of different phytochemicals.
Gaétan Tchangou Tabakam, Maurice Ducret Awouafack   +1 more
wiley   +1 more source

GC–MS‐Based Phytochemical Profiling and Integrated Evaluation of Antioxidant, Antibacterial, and In Silico Studies of Kumaun Himalayan Strobilanthes Species

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Himalayan Strobilanthes species: phytochemical profiling, bioactivities, and In silico Studies. ABSTRACT Five Strobilanthes species indigenous to the Kumaun Himalayan region of Uttarakhand, India, have been historically employed in traditional medicine to treat bacterial infections, inflammatory conditions, and respiratory ailments, but remain largely ...
Sakshi Negi, Ravendra Kumar, Vaishnavi Rawat, Pooja Bargali, Aashish Kumar Sagar, Stefania Garzoli, Riddhiman Lahiri, Shilpi Rawat, Avdhesh Kumar, Manmohan Singh Rawat, Jolanta Maslowiecka, Valery A. Isidorov, Dharmendra S. Rawat   +12 more
wiley   +1 more source

Evaluation of silvestrol as a potential therapeutic agent for pediatric COVID-19: an interpreted computational and phytochemistry approach

Frontiers in Pharmacology
BackgroundThe persistent COVID-19 disease, induced by SARS-CoV-2, sparked great questions about the safety and efficacy of the existing therapies in pediatric patients.
Yi Zhang, Shanshan Pu, Hui Wang
doaj   +1 more source

Measuring clinically relevant change in apathy symptoms in ADMET and ADMET 2

International Psychogeriatrics
Among participants with Alzheimer's disease (AD) we estimated the minimal clinically important difference (MCID) in apathy symptom severity on three scales.Retrospective anchor- and distribution-based analyses of change in apathy symptom scores.Apathy in Dementia Methylphenidate Trial (ADMET) and ADMET 2 randomized controlled trials conducted at three ...
Shankar Tumati, Nathan Herrmann, Jaime Perin, Paul B. Rosenberg, Alan J. Lerner, Jacobo Mintzer, Prasad R. Padala, Olga Brawman-Mintzer, Christopher H. van Dyck, Anton P. Porsteinsson, Suzanne Craft, Allan Levey, David Shade, Krista L. Lanctôt   +13 more
openaire   +2 more sources

Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin‐Based Quinazoline Derivatives as Potential Antidiabetic Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Sahil Jaidka, Ankush Kumar, Christopher Basumatary, Thakur Gurjeet Singh, Rohit Bhatia   +4 more
wiley   +1 more source