Results 101 to 110 of about 96,143 (246)

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis‐Chalcones as Potential COX‐2 Selective Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Novel polyhydroxylated bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition. The most potent and selective inhibitor exhibited a mixed‐type inhibition mechanism with COX‐2. Its additional bulk preferentially blocked the access to the active pocket of COX‐1 rather than COX‐2. Selective inhibition of COX‐2 is considered
Rui Pereira, Alberto N. Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C. Guedes, Vera L. M. Silva, Eduarda Fernandes   +7 more
wiley   +1 more source

Investigating emodin derivatives against SARS-CoV-2 found in medicinal herbs

Kuwait Journal of Science
SARS-CoV-2 continues to mutate and circulate at alarming levels around the world and is exemplified by the emergence of the new variant JN.1.
Usha T., Hemavathi K.N., Goyal A.K.
doaj   +1 more source

Bio-active components of Cymbopogon martinii essential oil as therapeutics targeting bacterial Penicillin-Binding-Proteins (PBPs): Aroma profile, in silico-docking, pharmacokinetics, and wet-lab validation

Journal of BioScience and Biotechnology, 2023
Cymbopogon martinii, also known as Palmarosa, is an underutilized plant in the tropical region. Due to its outstanding antioxidant potential, it has been used as a part of conventional medicine and beauty product.
Amrita Chauhan, Arun Dev Sharma, Inderjeet Kaur   +2 more
doaj  

Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa, Gabriella Spengler, Noémi Bózsity, Nikoletta Szemerédi, István Zupkó, Maria‐José U. Ferreira   +5 more
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix

Advanced Science, Volume 13, Issue 24, 27 April 2026.
A modular in vitro glioblastoma multiforme (GBM) model combining patient‐derived glioma stem‐like cells (GSC) organoid with an engineered extracellular matrix (eECM) and endothelial co‐culture enhances differentiation and GBM associated gene expression.
Autumn McManis, Charles Ashley Jimenez, Abha Shirolkar, Syed Raza ur Rehman, Sumana Mallick, Malea Murphy, Akhilesh K. Gaharwar, Irtisha Singh   +7 more
wiley   +1 more source

EQUIPMENT WITH HYDROSTATIC AMPLIFIER MODELED 3D

Journal of Industrial Design and Engineering Graphics, 2013
The equipment with hydrostatic amplifier is a new constructive solution modeled 3D using NX 7.5 software. Hydraulic equipment allows the amplification of a constant torque of a DC electric motor of low power at a variable speed.
EFTIMIE Dorin, FRONE Alexandru
doaj  

Elementary Games and Games Whose Correlated Equilibrium Polytope Has Full Dimension [PDF]

Un jeu est élémentaire s'il admet un équilibre corrélé strict à support plein. Un jeu est plein si le polytope de distributions d'équilibres corrélés à dimension pleine. Tout jeu élémentaire est plein.
Yannick Viossat
core  

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

The Theoretical Substantiation of the Targeted Search for New DPP4 Inhibitors. Computational Studies of Potential Candidates

Журнал органічної та фармацевтичної хімії
Growing evidence suggests that dipeptidyl peptidase 4 (DPP4) inhibitors, in addition to their role in improving glycemic control, help to reduce endothelial dysfunction and have hypolipidemic, anti-atherosclerotic, antitumor, antiviral, and neurotropic ...
Marharyta M. Suleiman, Аnton P. Semenets, Nataliia P. Kobzar, Lina O. Perekhoda   +3 more
doaj   +1 more source