Results 111 to 120 of about 96,143 (246)

The Dirichlet problem for superdegenerate differential operators

, 1998
Let $L$ be an infinitely degenerate second-order linear operator defined on a bounded smooth Euclidean domain. Under weaker conditions than those of H\"ormander, we show that the Dirichlet problem associated with $L$ has a unique smooth classical ...
Bell, Bell, Ben-Arous, Bony, Cattiaux, Denis R. Bell, Derridj, Jerison, Kusuoka, Malliavin, Salah-E.A. Mohammed, Stroock   +11 more
core   +1 more source

ADMET

Citation: 'ADMET' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12615 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Measuring clinically relevant change in apathy symptoms in ADMET and ADMET 2

International Psychogeriatrics
Among participants with Alzheimer's disease (AD) we estimated the minimal clinically important difference (MCID) in apathy symptom severity on three scales.Retrospective anchor- and distribution-based analyses of change in apathy symptom scores.Apathy in Dementia Methylphenidate Trial (ADMET) and ADMET 2 randomized controlled trials conducted at three ...
Shankar Tumati, Nathan Herrmann, Jaime Perin, Paul B. Rosenberg, Alan J. Lerner, Jacobo Mintzer, Prasad R. Padala, Olga Brawman-Mintzer, Christopher H. van Dyck, Anton P. Porsteinsson, Suzanne Craft, Allan Levey, David Shade, Krista L. Lanctôt   +13 more
openaire   +2 more sources

In Silico and In Vitro Antiurolithic Effect of Extracts, Fractions, and Isolated Compounds From Eugenia mattosii

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Urolithiasis, a condition characterized by the formation of calcium oxalate stones in the urinary tract, remains a significant clinical challenge due to the limited availability of effective preventive therapies. This study investigated the antiurolithic potential of different preparations from Eugenia mattosii, a plant rich in phenolic ...
Bianca Letícia Maciél, Luma Da Silva Portella, Camile Cecconi Cechinel‐Zanchett, Anelize Dada, Rita de Cássia Vilhena da Silva, Anelise Felício Macarini, Valdir Cechinel Filho, Priscila de Souza, Giovana Vechi   +8 more
wiley   +1 more source

Synthesis, Characterization, and Biological Evaluation of Aliphatic‐Substituted Benzimidazole Derivatives: Induction of Apoptosis, Cell Cycle Arrest, and Molecular Docking in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT A new series of aliphatic‐substituted benzimidazole derivatives was synthesized and structurally characterized to evaluate their potential anticancer activity. Among the synthesized compounds, compound 4 exhibited the most potent cytotoxic effects against MCF‐7 and MDA‐MB‐231 breast cancer cell lines, with IC₅₀ values comparable to those of ...
Murat Keser, Çisil Çamlı Pulat, Harika Atmaca, Hakan Akgün, Canan Albay, Emre Menteşe, Hakan Bektaş, Suleyman Ilhan   +7 more
wiley   +1 more source

Integrating virtual screening, pharmacoinformatics profiling, and molecular dynamics: identification of promising inhibitors targeting 3CLpro of SARS-CoV-2

Frontiers in Molecular Biosciences
Introduction: The pursuit of effective therapeutic solutions for SARS-CoV-2 infections and COVID-19 necessitates the repurposing of existing compounds. This study focuses on the detailed examination of the central protease, 3-chymotrypsin-like protease ...
Abeer Mohammad, Abeer Mohammad, Ahmed Zheoat, Amjad Oraibi, Amjad Oraibi, Amjad Oraibi, Ajay Manaithiya, Khalid S. Almaary, Hiba Allah Nafidi, Mohammed Bourhia, Soumaya Kilani-Jaziri, Soumaya Kilani-Jaziri, Yousef A. Bin Jardan   +12 more
doaj   +1 more source

Discovery of Capsazepine as a Novel MCL1 Inhibitor for Overcoming Tamoxifen Resistance in Breast Cancer Therapy

eFood, Volume 7, Issue 2, April 2026.
MCL1 in promoting tamoxifen resistance by inhibiting apoptosis. This study demonstrates that the compound CPZ, identified through virtual screening and validated by molecular docking and experiments, directly binds to MCL1. This binding restores apoptosis and inhibits tumor growth, thereby combating resistance to endocrine therapy in breast cancer ...
Shujing Liu, Jiayin Li, Chengkun Wu, Yupeng Xiao, Jing Yu, Yu Xie, Chen Lin, Chunhua Liu, Yue Wang, Junfang Qin   +9 more
wiley   +1 more source

Anti-anxiety properties of new 5H-2,3-benzodiazepine and 5H-[1,2,5]triazepine derivatives

Research Results in Pharmacology
Introduction: Previous studies have examined the anxiolytic properties of compounds containing mutually annulated systems of 5H-2,3-benzodiazepine and [1,2,4]triazole, namely 7H-[1,2,4]triazolo[3,4-a][2,3]benzodiazepine derivatives.
Maria O. Maltseva, Dmitriy V. Maltsev, Mikhail V. Miroshnikov, Lyudmila N. Divaeva, Anton O. Kharaneko, Oleg I. Kharaneko, Anatolii S. Morkovnik, Alexander A. Spasov   +7 more
doaj   +1 more source

Phyllanthus emblica Exerts Therapeutic Potential in Oral Cancer Through Multiple Pathways

eFood, Volume 7, Issue 2, April 2026.
Graphic Illustration of the Multifaceted Therapeutic Potential of PEWE, 1. Phyllanthus emblica water extract (PEWE) demonstrates potent anticancer effects against oral cancer by inhibiting cell proliferation, migration, and invasion while inducing apoptosis and autophagy. 2.
Tai‐Pei Lin, Min‐Hsiung Pan, Chan‐Hua Chang, Kuan‐Chung Hsiao, Yen‐Lin Chen, Jui‐Sheng Lai, Wen‐Chan Yang, Ann‐Joy Cheng, Yin‐Ju Chen, Chiou‐Ying Yang, Meng‐Yuan Huang, Ko‐Jiunn Liu   +11 more
wiley   +1 more source

In Silico Analysis of Phytochemicals of Native Pakistani Plants Having Antidiabetic Potential Targeting GLP‐1R and SGLT2 Proteins

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study examines the potential of phytochemicals from native Pakistani plants to mitigate the effects of diabetes by interacting with GLP‐1R and SGLT2 proteins using bioinformatics methods, thereby highlighting the application of bioinformatics in this context.
Malaika Ajaz, Waleed Rasool, Amna Mahmood, Faiyaz Ahmed, Anjum Khanam, Dua Zahra, Aqsa Jamshaid, Arooj Arshad, Fakhar Islam, Mohd Asif Shah   +9 more
wiley   +1 more source