Results 71 to 80 of about 96,143 (246)

Molecular modeling and pharmacokinetics studies of sulfamidophosphonate derivatives as potential candidate against Staphylococcus aureus

Eclética Química
In silico methods were used in this paper to assess the anti-bacterial activity of Sulfamidophosphonate derivatives against Staphylococcus aureus proteins (1XSD and 4WK3) using molecular docking and ADMET analysis.
Abimbola Modupe Olatunde, Kehinde Gabriel Obiyenwa, Tofunmi Emmanuel Oladuji, Dayo Felix Latona, Abel Kolawole Oyebamiji, Nathaniel Oladoye Olatunji, Banjo Semire   +6 more
doaj   +1 more source

Asymptotic description of stochastic neural networks. II - Characterization of the limit law [PDF]

, 2014
We continue the development, started in of the asymptotic description of certain stochastic neural networks. We use the Large Deviation Principle (LDP) and the good rate function H announced there to prove that H has a unique minimum mu_e, a stationary ...
Faugeras, Olivier, MacLaurin, James
core   +7 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Geometry Optimization, Molecular Docking and ADMET Studies of Echimidine Molecule

Cumhuriyet Science Journal
Plants are an important food group that has been used as a source of nutrition and healing from past to present. Plants contain secondary metabolites that are still under investigation in drug development studies.
Bilge Bıçak
doaj   +1 more source

Stability and computational analyses of selected pesticides in use in the Republic of Serbia [PDF]

Journal of the Serbian Chemical Society
Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated.
Arsić Biljana, Petrović Stefan, Mrmošanin Jelena, Dimitrijević Ivana, Tošić Snežana, Stojanović Gordana, Glišić Sanja, Milićević Jelena   +7 more
doaj   +1 more source

Triazolinedione-'clicked' poly(phosphoester)s : systematic adjustment of thermal properties [PDF]

, 2017
The thermal properties of halogen-free flame retardant poly(phosphoester)s from acyclic diene metathesis polycondensation have been optimized by a systematic post-modification using 1,2,4-triazoline- 3,5-dione derivatives.
Becker, Greta, Du Prez, Filip, Velencoso, Maria M, Vlaminck, Laetitia, Wurm, Frederik R   +4 more
core   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

A New Candidate for the Treatment of Alzheimer's Disease; Synthesis, Characterization, Investigation of Drug Properties with In Silico Methods

Cumhuriyet Science Journal
Brain disorder-caused mortality has emerged as the second of all diseases worldwide in the 21st century. Alzheimer’s Disease (AD) is the most common disease that takes place among brain disorders according to statistics.
Tolga Acar Yeşil, Tahir Tilki, Ömer Dilek   +2 more
doaj   +1 more source

Insights into the molecular basis of some chalcone analogues as potential inhibitors of Leishmania donovani: An integrated in silico and in vitro study

Open Chemistry, 2022
Protozoal infections caused by species belonging to Leishmania donovani complex are responsible for the most severe form of leishmaniasis, especially in Sudan and other developing countries.
Osman Marwa S., Awad Talal A., Shantier Shaza W., Garelnabi Elrashied A. E., Mukhtar Moawia M., Osman Wadah, Mothana Ramzi A., Elhag Rashid I.   +7 more
doaj   +1 more source

Hydroxyl‐Terminated Polybutadiene‐Based Molding Powders as an Alternative Route for Manufacturing Pressed Polymer‐Bonded Explosives

Propellants, Explosives, Pyrotechnics, EarlyView.
This study presents an alternative method to manufacture polymer‐bonded explosives by partially curing an HTPB‐based molding powder prior to compaction. The study shows that the length of partial cure time before compaction directly influenced the geometric fidelity, homogeneity, compressive strength, density, and internal microstructure.
Ismar L. Chew, Cole Stephens, Ellen Ma, Julio Hernandez, Monique S. McClain   +4 more
wiley   +1 more source