Results 51 to 60 of about 28,615 (245)

Formulation and evaluation of a mucoadhesive buccal tablet of mefenamic acid

Brazilian Journal of Pharmaceutical Sciences, 2020
Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate mucoadhesive buccal tablet using Mefenamic acid and compatible excipients, and to ...
Karen Lu Li, Agnes Llamasares Castillo
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery

Nature Communications, 2021
Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge.
Shanshan Hu, Xibo Pei, Lunliang Duan, Zhou Zhu, Yanhua Liu, Junyu Chen, Tao Chen, Ping Ji, Qianbing Wan, Jian Wang   +9 more
doaj   +1 more source

Biopharmaceutical Study of Triamcinolone Acetonide Semisolid Formulations for Sublingual and Buccal Administration

Pharmaceutics, 2021
The mouth can be affected by important inflammatory processes resulting from localized or systemic diseases such as diabetes, AIDS and leukemia, among others, and are manifested in various types of buccal sores typically presenting pain.
Marta Márquez Valls, Alejandra Martínez Labrador, Lyda Halbaut Bellowa, Doménica Bravo Torres, Paulo C. Granda, Montserrat Miñarro Carmona, David Limón, Ana C. Calpena Campmany   +7 more
doaj   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source

Protective effect of coumarin on cell surface glycoconjugates abnormalities during 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinogenesis [PDF]

International Journal of Biological and Medical Research, 2011
Aims: The major aims of the present study was to focus the protective effect of coumarin on cell surface glycoconjugates abnormalities during 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Methods: DMBA painting in the
Nagarethinam Baskaran, Shanmugam Manoharan, Simon Silvan, Duraisamy Palanimuthu,Duraisamy Rajasekaran, Murugaraj Manoj Prabhakar, Sekar Karthikeyan,Ramachandran Srinivasan and Shamsul Afaq Wani   +2 more
doaj  

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

PHARMACOKINETICS OF MORPHINE FOLLOWING ADMINISTRATION BY THE BUCCAL ROUTE

British Journal of Anaesthesia, 1989
The pharmacokinetics of morphine administered via the buccal route as a controlled release formulation were assessed after the administration of three different doses and found to be linear in the dose range 10-30 mg. The plasma concentrations of morphine-3-glucuronide and morphine-6-glucuronide demonstrated considerable inter-subject variation and ...
A R, Manara, M P, Shelly, K G, Quinn, G R, Park   +3 more
openaire   +2 more sources

Absorption of clonazepam after intranasal and buccal administration. [PDF]

British Journal of Clinical Pharmacology, 1995
Serum concentrations of clonazepam after intranasal, buccal and intravenous administration were compared in a cross‐over study in seven healthy male volunteers. Each subject received a 1.0 mg dose of clonazepam intranasally and buccally and 0.5 mg intravenously.
M W, Schols-Hendriks, J J, Lohman, R, Janknegt, J J, Korten, F W, Merkus, P M, Hooymans   +5 more
openaire   +2 more sources

AI‐Driven Predictive Design and Functionalization of Three Dimensional‐Printed PEEK Implants with Tryptophan‐Enriched Alginate Hydrogel for Enhanced Biomimetic Surface Performance

Advanced Intelligent Systems, EarlyView.
This study introduces an AI‐guided strategy to design 3D‐printed PEEK implants functionalized with a tryptophan‐enriched alginate hydrogel (TRYALPEEK). The modification improves hydrophilicity, reduces surface roughness, enhances cytocompatibility, and optimizes stress distribution. The platform offers a promising route for personalized implant design,
Wafa Benaatou, Desirae Nance, Denisse A Gutierrez, Renato J Aguilera, Armando Varela‐Ramirez, Filiz Yagci, Emir Esim, Mahesh Narayan, Mohamed Noufal   +8 more
wiley   +1 more source