Results 151 to 160 of about 117,049 (245)

Pharmacovigilance study for the identification of mogamulizumab-induced immune-related adverse events using a real-world database. [PDF]

Oncologist
Miyata K, Izawa-Ishizawa Y, Niimura T, Yoshioka T, Hyodo M, Itokazu S, Miyata T, Aizawa F, Yagi K, Kawada K, Hamano H, Zamami Y, Goda M, Ishizawa K.   +13 more
europepmc   +1 more source

Streamlining Vorinostat Synthesis: A Chemoenzymatic Continuous Flow Approach

European Journal of Organic Chemistry, EarlyView.
A chemoenzymatic protocol for the synthesis of histone deacetylase inhibitor vorinostat has been established. Immobilized lipase from C. antarctica (imm‐CaLB) allowed the functionalization of suberanoyl acid 1 and further conversion to vorinostat via ion‐exchange resin treatment.
Francesca Annunziata, Lucia Tamborini, Andrea Pinto, Michail S. Christodoulou, Sabrina Dallavalle, Salvatore Princiotto, Martina L. Contente   +6 more
wiley   +1 more source

Multi-Organ Adverse Reaction to Two Hypomethylating Agents: A Challenge in High-Risk Myelodysplastic Syndrome Treatment. [PDF]

Hematol Rep
Alves SB, Pierdomenico F.
europepmc   +1 more source

Neuronal surface and intracellular antibody testing in patients with long‐term epilepsy

Epilepsia Open, EarlyView.
Abstract Objective We aimed to investigate the frequency of neuronal surface and intracellular antibodies in individuals with long‐term epilepsy and the associated clinical and laboratory characteristics. Methods We tested sera from 223 patients with epilepsy without signs of autoimmune encephalitis and 12 patients with epilepsy and a subacute onset of
Nancy Watanabe, Angelica Lizcano, Tânia K. de Araujo, Renata Barbosa, Marina K. M. Alvim, Andre S. Vieira, Iscia Lopes‐Cendes, Fabio Rogerio, Clarissa L. Yasuda, Fernando Cendes   +9 more
wiley   +1 more source

Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine. [PDF]

Brain
Kopruszinski CM, Linley JE, Thornton P, Walker AS, Newton P, Podichetty S, Ruparel RH, Moreira de Souza LH, Navratilova E, Meno-Tetang G, Gurrell I, Dodick DW, Dobson C, Chessell T, Porreca F, Chessell I.   +15 more
europepmc   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Exposed Necrotic Bone in a Head and Neck Cancer Patient: Report of a Diagnostic Challenge. [PDF]

Diagnostics (Basel)
Dell'Olio F, Siciliani RA, Forte M, Capodiferro S, Favia G, Limongelli L.   +5 more
europepmc   +1 more source

Ultra‐Hypofractionated Radiotherapy for Early‐Stage Glottic Cancer: Real‐World Data From a Single Center

Head &Neck, EarlyView.
ABSTRACT Background In recent years, smaller‐volume radiotherapy has attracted attention. It appears to be a safe and effective treatment for glottic laryngeal cancer. This study evaluated the results of ultra‐hypofractionated radiotherapy for early glottic laryngeal cancer in unfit patients.
Mete Gundog, Esin Kiraz
wiley   +1 more source

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, EarlyView.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source

New-onset dermatomyositis in a patient on nivolumab for metastatic melanoma. [PDF]

BMJ Case Rep
Curkovic NB, Johnson DB, Parker ER.
europepmc   +1 more source