Results 111 to 120 of about 1,979,787 (310)

Repeated inhalation of crack-cocaine affects spermatogenesis in young and adult mice

, 2012
To investigate the effects of repeated crack-cocaine inhalation on spermatogenesis of pubertal and mature Balb/c mice, ten young (Y-ex) and ten adult (A(ex)) Balb/c mice were exposed to the smoke from 5 g of crack with 57.7% of pure cocaine in an ...
Santos, A. B. G., Hage, M., Medeiros, M. C. R., Zorzetto, J. C., Garcia, R. C. T., Bueno, H. M. S., Pieri, P., Yonamine, M., Saldiva, P. H. N., Pires, A., Hallak, J.   +10 more
core   +1 more source

Formulation pre-screening of inhalation powders using computational atom-atom systematic search method. [PDF]

, 2015
The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes.
Jaffari, Sara, Soufian, Majeed, Roberts, Kevin J., Darragh Murnane (1348947), Soufian, M, Jaffari, S, Vasuki Ramachandran, Forbes, Ben, Elizabeth Collins, Jonathan Pickering, Ramachandran, V, Martin, GP, Robert B. Hammond (1348938), Klimentina Pencheva, Gary P. Martin (1348953), Collins, E, Vasuki Ramachandran (1348941), Collins, Elizabeth, Pencheva, K, Roberts, KJ, Elizabeth Collins (1348959), Klimentina Pencheva (1348962), Ben Forbes, Hammond, Robert B., Gary P. Martin, Pickering, Jonathan, Murnane, Darragh, Robert B. Hammond, Kevin J. Roberts (1348965), Ramachandran, Vasuki, Martin, Gary P., Jonathan Pickering (1348968), Kevin J. Roberts, Murnane, D, Sara Jaffari (1348956), Darragh Murnane, Sara Jaffari, Hammond, RB, Forbes, B, Majeed Soufian (1348944), Majeed Soufian, Pickering, J, Ben Forbes (1348950), Pencheva, Klimentina   +43 more
core   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Preparation, quality evaluation and preliminary pharmacokinetic-pharmacodynamic studies of synephrine dry powder inhaler

Drug Delivery
Acute lung injury (ALI) is a lung disease characterized by pulmonary edema caused by an excessive inflammatory response within the lungs and disruption of the alveolar capillary barrier, with a high morbidity and mortality rate in critically ill patients.
Jiming Ke, Shenao Li, Miaomiao Zi, Jing Zhang, Shan Huang, Wenhui Luo, Hailun Han, Jiwen Zhang, Can Peng   +8 more
doaj   +1 more source

Inhalation therapy in children [PDF]

, 2014
Inhalation is a form of treatment used in respiratory diseases that allows medications to be administered directly to the affected site. Thanks to this, the administration of lower doses helps obtain a higher concentration in the target organ and ...
Jolanta Pietrzak, Anna Obuchowicz, Kowol-Trela, Katarzyna, Pietrzak, Jolanta, Katarzyna Kowol-Trela, Obuchowicz, Anna   +5 more
core   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Novel devices for individualized controlled inhalation can optimize aerosol therapy in efficacy, patient care and power of clinical trials

European Journal of Medical Research, 2009
In the treatment of pulmonary diseases the inhalation of aerosols plays a key role - it is the preferred route of drug delivery in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
Fischer A, Stegemann J, Scheuch G, Siekmeier R   +3 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Ethanol Enhanced in Vivo Gene Delivery with Non-Ionic Polymeric Micelles Inhalation

, 2008
Modifications of both carriers and host barriers have been investigated for efficient inhalation gene delivery to lung. Here we used a biocompatible, non-ionic poly(ethyleneoxide) -poly(propyleneoxide)-poly( ethyleneoxide) (PEO-PPO-PEO) polymeric ...
Chao, Yen-Chin; Chang, Shwu-Fen; Lu, Shao-Chun; Hwang, Tzyh-Chang; Hsieh, Wei-Hsien; Liaw, Jiahorng, 張淑芬;呂紹俊   +1 more
core  

Oxytocin Increases Bias, but not Accuracy, in Face Recognition Line-Ups [PDF]

, 2014
Previous work indicates that intranasal inhalation of oxytocin improves face recognition skills, raising the possibility that it may be used in security settings. However, it is unclear whether oxytocin directly acts upon the core face-processing system
Bate, Sarah, Parris, Benjamin, Udale, R, Parris, BA, Bennetts, Rachel, Bussunt, A, Bindemann, Markus, Bindemann, M, Bussunt, A., Udale, Robert, Bennetts, R, Bindemann, M., Bate, S   +12 more
core   +1 more source