Results 101 to 110 of about 2,696,581 (351)

In vitro atomization analysis and evaluation of inhalable sodium sivelestat formulations.

open access: yesPLoS ONE
The purpose of this paper was to study in vitro atomization properties of the self-developed sodium sivelestat for inhalation, evaluate the feasibility of this preparation as an aerosol inhalation, and provide the guidance for the following animal ...
Rangdong Liu   +4 more
doaj   +1 more source

THE EFFECT OF N-ACETYL CYSTEINE TO SPERM MOTILITY, VIABILITY, AND CONCENTRATION OF SPRAGUE DAWLEY RATS WITH NICOTINE INHALATION EXPOSURE

open access: yesJurnal Urologi Indonesia, 2019
Objective: To prove and analyze the difference of sperm motility, viability, and concentration of Sprague Dawley rats which were exposed to nicotine inhalation, with rats treated with N-acetyl cysteine (NAC) orally and exposed to nicotine inhalation ...
Dwi Waskito   +2 more
doaj   +1 more source

Microspheres Based on a Protein Matrix and Dipyridamole with Possible Inhalation Administration

open access: yes, 2021
Inhalation delivery is a promising way of administration of antiplatelet drugs for the prevention of stroke. The bioavailability of drugs poorly soluble in water can be increased if microspheres based on protein molecules are used.
Ziganshin M.A.   +4 more
core  

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

open access: yesAdvanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao   +11 more
wiley   +1 more source

Matrix metalloproteinase 2/9-triggered-release micelles for inhaled drug delivery to treat lung cancer: preparation and in vitro/in vivo studies

open access: yesInternational Journal of Nanomedicine, 2018
Xiaofei Wang,1,2 Qinyue Chen,1 Xiaoyan Zhang,1 Xiaoqing Ren,1 Xiulei Zhang,1 Lin Meng,1 Huihui Liang,1 Xianyi Sha,1 Xiaoling Fang1 1Key Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai ...
Wang X   +8 more
doaj  

Exposure facilities and aerosol generation and characterization for inhalation experiments

open access: yes, 2022
S.67-85 : Abb.,Lit.Starting with an introduction to particle deposition in the respiratory tracts of human and animals, it is discussed which criteria have to be met by exposure facilities in order to facilitate reliable administration of aerosol ...
Holländer, W.
core  

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

open access: yesAdvanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang   +14 more
wiley   +1 more source

Effect of Kaempferol on Cyclooxygenase 2 (Cox2) and Cytosolic Phospholipase A2 (cPLA2) Protein Expression in BALB/c Mice

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2018
Kaempferol, a phytochemical found in many edible plants, is known to alleviate diseases such as cancer, allergy, and inflammation. The objective of this study was to investigate whether kaempferol could reduce omega-6 and ovalbumin-mediated allergic ...
Da Rae Kang   +4 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao   +11 more
wiley   +1 more source

Endothelin-1 in Citric Acid Aerosol Inhalation-Induced Airway Constriction of Guinea Pigs

open access: yes, 2009
Endotheline-1 (ET-1) has been shown to enhance tachykinin-induced airway constriction. This study was designed to test whether ET-1 is involved in citric acid-induced bronchoconstriction.
LI, SHU-CHEN;LAI, YIH-LOONG   +1 more
core  

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