Results 91 to 100 of about 220,199 (312)
International Journal of Nanomedicine, 2018 Xiaofei Wang,1,2 Qinyue Chen,1 Xiaoyan Zhang,1 Xiaoqing Ren,1 Xiulei Zhang,1 Lin Meng,1 Huihui Liang,1 Xianyi Sha,1 Xiaoling Fang1 1Key Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai ...
Wang X +8 more
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International Journal of Pharmaceutics: XMulberry Diels-Alder-type adducts (MDAAs), isolated from Morus alba root bark, exhibit dual activity against viral and bacterial pathogens but show sobering efficacy following oral administration.
Jacqueline Schwarzinger +9 more
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Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]
, 2018 BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.
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Advanced Robotics Research, EarlyView.A soft robotic simulator is developed to replicate the digital removal of feces (DRF), a sensitive yet essential nursing procedure. Integrating soft actuators, sensors, and a realistic rectal model, the simulator balances functional fidelity with perceptual realism. Engineering evaluations and nurse feedback confirm its potential to enhance training in
Shoko Miyagawa +10 more
wiley +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2018 Kaempferol, a phytochemical found in many edible plants, is known to alleviate diseases such as cancer, allergy, and inflammation. The objective of this study was to investigate whether kaempferol could reduce omega-6 and ovalbumin-mediated allergic ...
Da Rae Kang +4 more
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High concentrations of flavor chemicals are present in electronic cigarette refill fluids. [PDF]
, 2019 We characterized the flavor chemicals in a broad sample of commercially available electronic cigarette (EC) refill fluids that were purchased in four different countries.
Luo, Wentai +5 more
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Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury
Advanced Science, EarlyView.IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang +18 more
wiley +1 more source
Midazolam Efficacy Against Acute Hydrogen Sulfide-Induced Mortality and Neurotoxicity. [PDF]
, 2018 Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while
Anantharam, Poojya +6 more
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Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source